Inhibition of platelet-activating factor receptor binding by aporphine and phenanthrenoid alkaloids from Aromadendron elegans

Ibrahim Jantan, I. A A Rafi, Juriyati Jalil

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Six aporphine and one phenanthrenoid alkaloids isolated from Aromadendron elegans Blume were investigated for their inhibitory effect on platelet-activating factor (PAF) binding to rabbit platelets using 3H-PAF as a ligand. Of the compounds tested, (-)-N-acetylanonaine, 1-(N-acetyl-N-methylamino)ethyl-3,4,6-trimethoxy-7-hydroxy-phenanthrene, and predicentrine showed strong inhibition of PAF receptor binding, with IC50 values of 52.4, 38.6, and 29.8 μM, respectively. The flexibility of the biphenyl system of the aporphine and the presence of methoxy groups at C-9 and C-10 were all preferable in binding to the receptor.

Original languageEnglish
Pages (from-to)466-467
Number of pages2
JournalPlanta Medica
Volume67
Issue number5
DOIs
Publication statusPublished - 2001

Fingerprint

platelet-activating factor
Platelet Activating Factor
Alkaloids
alkaloids
receptors
Platelets
Inhibitory Concentration 50
phenanthrene
Blood Platelets
Rabbits
Ligands
biphenyl
inhibitory concentration 50
rabbits
platelet activating factor receptor
aporphine
diphenyl

ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Inhibition of platelet-activating factor receptor binding by aporphine and phenanthrenoid alkaloids from Aromadendron elegans. / Jantan, Ibrahim; Rafi, I. A A; Jalil, Juriyati.

In: Planta Medica, Vol. 67, No. 5, 2001, p. 466-467.

Research output: Contribution to journalArticle

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