Influenza virus shedding in laninamivir-treated children upon returning to school

Hiroki Kondo, Yugo Shobugawa, Akinobu Hibino, Ren Yagami, Clyde Dapat, Minoru Okazaki, Taketo Otsuka, Koyata Fujii, Mohd Rohaizat Hassan, Reiko Saito

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The current School Health and Safety Act in Japan states that children with influenza infection should stay home until day 6th after symptoms onset. This was an amendment of a previous version recommending school return on day 3 after defervescence. Here, we investigated the duration of fever and virus shedding after laninamivir treatment in 7 children infected with influenza A(H3N2) virus and 21 children with influenza B virus in relation to the school return timing recommended by the School Health and Safety Act during the 2011-2012 influenza season. Nasal discharge was collected on the first, second, and third hospital visits and virus titers were assessed by virus culture and real-time PCR. Duration of fever after laninamivir treatment was 1 day longer for influenza B than for influenza A(H3N2). Virus detection rates with 50% tissue culture infectious dose and viral RNA were highest at the first visit and gradually decreased at subsequent visits. Virus positivity rates were detectable at the time of defervescence in less than half of the enrolled patients (14.3-42.9%). Virus shedding rates were similarly low (0.0-19.0%) on day 3 or later from defervescence and on day 6 or later from fever onset (school return dates per the old and current School Health and Safety Act) regardless of the influenza type. In conclusion, despite the higher efficacy of laninamivir against A(H3N2) viruses than B viruses, viral shedding is low after return to school for both types, regardless of the version of the School Health and Safety Act.

Original languageEnglish
Pages (from-to)113-121
Number of pages9
JournalTohoku Journal of Experimental Medicine
Volume238
Issue number2
DOIs
Publication statusPublished - 23 Jan 2016

Fingerprint

R 125489
Virus Shedding
Orthomyxoviridae
Viruses
School Health Services
Human Influenza
H3N2 Subtype Influenza A Virus
Safety
Fever
Health
Influenza B virus
Cercopithecine Herpesvirus 1
Influenza A virus
Viral RNA
Viral Load
Nose
Real-Time Polymerase Chain Reaction
Japan
Tissue culture

Keywords

  • Influenza
  • Laninamivir
  • Period of school absence
  • School health
  • Virus shedding

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Kondo, H., Shobugawa, Y., Hibino, A., Yagami, R., Dapat, C., Okazaki, M., ... Saito, R. (2016). Influenza virus shedding in laninamivir-treated children upon returning to school. Tohoku Journal of Experimental Medicine, 238(2), 113-121. https://doi.org/10.1620/tjem.238.113

Influenza virus shedding in laninamivir-treated children upon returning to school. / Kondo, Hiroki; Shobugawa, Yugo; Hibino, Akinobu; Yagami, Ren; Dapat, Clyde; Okazaki, Minoru; Otsuka, Taketo; Fujii, Koyata; Hassan, Mohd Rohaizat; Saito, Reiko.

In: Tohoku Journal of Experimental Medicine, Vol. 238, No. 2, 23.01.2016, p. 113-121.

Research output: Contribution to journalArticle

Kondo, H, Shobugawa, Y, Hibino, A, Yagami, R, Dapat, C, Okazaki, M, Otsuka, T, Fujii, K, Hassan, MR & Saito, R 2016, 'Influenza virus shedding in laninamivir-treated children upon returning to school', Tohoku Journal of Experimental Medicine, vol. 238, no. 2, pp. 113-121. https://doi.org/10.1620/tjem.238.113
Kondo, Hiroki ; Shobugawa, Yugo ; Hibino, Akinobu ; Yagami, Ren ; Dapat, Clyde ; Okazaki, Minoru ; Otsuka, Taketo ; Fujii, Koyata ; Hassan, Mohd Rohaizat ; Saito, Reiko. / Influenza virus shedding in laninamivir-treated children upon returning to school. In: Tohoku Journal of Experimental Medicine. 2016 ; Vol. 238, No. 2. pp. 113-121.
@article{4c56a99441e74703bc9a9e371e797ef0,
title = "Influenza virus shedding in laninamivir-treated children upon returning to school",
abstract = "The current School Health and Safety Act in Japan states that children with influenza infection should stay home until day 6th after symptoms onset. This was an amendment of a previous version recommending school return on day 3 after defervescence. Here, we investigated the duration of fever and virus shedding after laninamivir treatment in 7 children infected with influenza A(H3N2) virus and 21 children with influenza B virus in relation to the school return timing recommended by the School Health and Safety Act during the 2011-2012 influenza season. Nasal discharge was collected on the first, second, and third hospital visits and virus titers were assessed by virus culture and real-time PCR. Duration of fever after laninamivir treatment was 1 day longer for influenza B than for influenza A(H3N2). Virus detection rates with 50{\%} tissue culture infectious dose and viral RNA were highest at the first visit and gradually decreased at subsequent visits. Virus positivity rates were detectable at the time of defervescence in less than half of the enrolled patients (14.3-42.9{\%}). Virus shedding rates were similarly low (0.0-19.0{\%}) on day 3 or later from defervescence and on day 6 or later from fever onset (school return dates per the old and current School Health and Safety Act) regardless of the influenza type. In conclusion, despite the higher efficacy of laninamivir against A(H3N2) viruses than B viruses, viral shedding is low after return to school for both types, regardless of the version of the School Health and Safety Act.",
keywords = "Influenza, Laninamivir, Period of school absence, School health, Virus shedding",
author = "Hiroki Kondo and Yugo Shobugawa and Akinobu Hibino and Ren Yagami and Clyde Dapat and Minoru Okazaki and Taketo Otsuka and Koyata Fujii and Hassan, {Mohd Rohaizat} and Reiko Saito",
year = "2016",
month = "1",
day = "23",
doi = "10.1620/tjem.238.113",
language = "English",
volume = "238",
pages = "113--121",
journal = "Tohoku Journal of Experimental Medicine",
issn = "0040-8727",
publisher = "Tohoku University Medical Press",
number = "2",

}

TY - JOUR

T1 - Influenza virus shedding in laninamivir-treated children upon returning to school

AU - Kondo, Hiroki

AU - Shobugawa, Yugo

AU - Hibino, Akinobu

AU - Yagami, Ren

AU - Dapat, Clyde

AU - Okazaki, Minoru

AU - Otsuka, Taketo

AU - Fujii, Koyata

AU - Hassan, Mohd Rohaizat

AU - Saito, Reiko

PY - 2016/1/23

Y1 - 2016/1/23

N2 - The current School Health and Safety Act in Japan states that children with influenza infection should stay home until day 6th after symptoms onset. This was an amendment of a previous version recommending school return on day 3 after defervescence. Here, we investigated the duration of fever and virus shedding after laninamivir treatment in 7 children infected with influenza A(H3N2) virus and 21 children with influenza B virus in relation to the school return timing recommended by the School Health and Safety Act during the 2011-2012 influenza season. Nasal discharge was collected on the first, second, and third hospital visits and virus titers were assessed by virus culture and real-time PCR. Duration of fever after laninamivir treatment was 1 day longer for influenza B than for influenza A(H3N2). Virus detection rates with 50% tissue culture infectious dose and viral RNA were highest at the first visit and gradually decreased at subsequent visits. Virus positivity rates were detectable at the time of defervescence in less than half of the enrolled patients (14.3-42.9%). Virus shedding rates were similarly low (0.0-19.0%) on day 3 or later from defervescence and on day 6 or later from fever onset (school return dates per the old and current School Health and Safety Act) regardless of the influenza type. In conclusion, despite the higher efficacy of laninamivir against A(H3N2) viruses than B viruses, viral shedding is low after return to school for both types, regardless of the version of the School Health and Safety Act.

AB - The current School Health and Safety Act in Japan states that children with influenza infection should stay home until day 6th after symptoms onset. This was an amendment of a previous version recommending school return on day 3 after defervescence. Here, we investigated the duration of fever and virus shedding after laninamivir treatment in 7 children infected with influenza A(H3N2) virus and 21 children with influenza B virus in relation to the school return timing recommended by the School Health and Safety Act during the 2011-2012 influenza season. Nasal discharge was collected on the first, second, and third hospital visits and virus titers were assessed by virus culture and real-time PCR. Duration of fever after laninamivir treatment was 1 day longer for influenza B than for influenza A(H3N2). Virus detection rates with 50% tissue culture infectious dose and viral RNA were highest at the first visit and gradually decreased at subsequent visits. Virus positivity rates were detectable at the time of defervescence in less than half of the enrolled patients (14.3-42.9%). Virus shedding rates were similarly low (0.0-19.0%) on day 3 or later from defervescence and on day 6 or later from fever onset (school return dates per the old and current School Health and Safety Act) regardless of the influenza type. In conclusion, despite the higher efficacy of laninamivir against A(H3N2) viruses than B viruses, viral shedding is low after return to school for both types, regardless of the version of the School Health and Safety Act.

KW - Influenza

KW - Laninamivir

KW - Period of school absence

KW - School health

KW - Virus shedding

UR - http://www.scopus.com/inward/record.url?scp=84955490666&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84955490666&partnerID=8YFLogxK

U2 - 10.1620/tjem.238.113

DO - 10.1620/tjem.238.113

M3 - Article

VL - 238

SP - 113

EP - 121

JO - Tohoku Journal of Experimental Medicine

JF - Tohoku Journal of Experimental Medicine

SN - 0040-8727

IS - 2

ER -