Influences on bone mineral density in Malaysian premenopausal systemic lupus erythematosus patients on corticosteroids

S. S. Yeap, A. R. Fauzi, N. C T Kong, Abdul Halim Abdul Gafor, Z. Soehardy, S. Rahimah, S. K. Chow, E. M L Goh

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Abstract

The aim of this study was to assess the bone mineral density (BMD) of premenopausal patients with systemic lupus erythematosus (SLE) on corticosteroids (CS) and to determine the influence of CS and other risk factors on BMD. A total of 98 premenopausal patients with SLE were recruited from outpatient clinics in two teaching hospitals. Risk factors for osteoporosis were determined, and BMD wasmeasured using dual-energy x-ray absorptiometry. The mean age of the patients was 30.05 ± 7.54 years. The mean dose of prednisolone at time of BMD measurement was 18.38 ± 10.85 mg daily. Median duration of CS use was 2.5 years (range 0-20).Median cumulative dose of CS was 9.04 g (range 0.28-890.0). Six patients (6.1%) had osteoporosis, 41 (41.9%) had osteopenia and 51 (52.0%) had normal BMD. Lumbar spine T score correlated with cumulative CS dose (P = 0.019). Duration of CS intake correlated with femoral neck T score (P = 0.04) and trochanter T score (P = 0.008). There was no correlation between BMD and race, SLE Disease Activity Index score, smoking and self-reported calcium intake or exercise. Only 52% of these patients had normal BMD. The duration and cumulative dose of CS intake was significantly correlated to BMD, but not the other commonly assessed risk factors. These findings suggest that premenopausal patients with SLE on CS should have their BMD measured at regular intervals to fully assess their osteoporosis risk.

Original languageEnglish
Pages (from-to)178-181
Number of pages4
JournalLupus
Volume18
Issue number2
DOIs
Publication statusPublished - Feb 2009

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Systemic Lupus Erythematosus
Bone Density
Adrenal Cortex Hormones
Osteoporosis
Metabolic Bone Diseases
Femur Neck
Prednisolone
Ambulatory Care Facilities
Teaching Hospitals
Femur
Spine
Smoking
X-Rays
Exercise
Calcium

Keywords

  • Bone mineral density
  • Corticosteroids
  • Osteoporosis
  • SLE

ASJC Scopus subject areas

  • Rheumatology

Cite this

Influences on bone mineral density in Malaysian premenopausal systemic lupus erythematosus patients on corticosteroids. / Yeap, S. S.; Fauzi, A. R.; Kong, N. C T; Abdul Gafor, Abdul Halim; Soehardy, Z.; Rahimah, S.; Chow, S. K.; Goh, E. M L.

In: Lupus, Vol. 18, No. 2, 02.2009, p. 178-181.

Research output: Contribution to journalArticle

Yeap, S. S. ; Fauzi, A. R. ; Kong, N. C T ; Abdul Gafor, Abdul Halim ; Soehardy, Z. ; Rahimah, S. ; Chow, S. K. ; Goh, E. M L. / Influences on bone mineral density in Malaysian premenopausal systemic lupus erythematosus patients on corticosteroids. In: Lupus. 2009 ; Vol. 18, No. 2. pp. 178-181.
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