Influence of poly (Ethylene glycol) on the characteristics of γ radiation-Crosslinked poly (Vinyl pyrrolidone)-Low molecular weight chitosan network hydrogels

Maznah Mahmud, Rusli Daik, Zainah Adam

Research output: Contribution to journalArticle

Abstract

PEG at compositions of 10, 15 and 20 g were added into the initial formulation of hydrogel L, which was composed of 6 g low molecular weight chitosan (LMC) and 14 g poly (vinyl pyrrolidone) in 100 g of 2% lactic acid. The mixtures were moulded and exposed to γ radiation at 7 kGy. The hydrogels obtained were characterized in term of gel fraction, swelling property, syneresis effect, FTIR, XRD and cross section morphology. The results indicated PEG reduces almost 27% crosslinking density of the LMC-PVP hydrogel yet increased hydrogel’s water holding capacity from 450% and 480% to 750% and 650% in phosphate buffer solution (PBS) at pH5.5 and pH7.0, respectively. Also PEG enhanced the ability of LMC-PVP hydrogel to retain its moisture from dehydration at body temperature. The morphological study showed PEG developed thick pores wall and reduced the pores size of the hydrogels’ network.

Original languageEnglish
Pages (from-to)1189-1197
Number of pages9
JournalSains Malaysiana
Volume47
Issue number6
DOIs
Publication statusPublished - 1 Jun 2018

Fingerprint

hydrocolloids
polyethylene glycol
chitosan
molecular weight
crosslinking
water holding capacity
lactic acid
body temperature
pyrrolidones
buffers
gels
phosphates

Keywords

  • Covalent-crosslink
  • Plasticizer
  • Porosity
  • Swelling-equilibrium
  • Syneresis

ASJC Scopus subject areas

  • General

Cite this

Influence of poly (Ethylene glycol) on the characteristics of γ radiation-Crosslinked poly (Vinyl pyrrolidone)-Low molecular weight chitosan network hydrogels. / Mahmud, Maznah; Daik, Rusli; Adam, Zainah.

In: Sains Malaysiana, Vol. 47, No. 6, 01.06.2018, p. 1189-1197.

Research output: Contribution to journalArticle

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AB - PEG at compositions of 10, 15 and 20 g were added into the initial formulation of hydrogel L, which was composed of 6 g low molecular weight chitosan (LMC) and 14 g poly (vinyl pyrrolidone) in 100 g of 2% lactic acid. The mixtures were moulded and exposed to γ radiation at 7 kGy. The hydrogels obtained were characterized in term of gel fraction, swelling property, syneresis effect, FTIR, XRD and cross section morphology. The results indicated PEG reduces almost 27% crosslinking density of the LMC-PVP hydrogel yet increased hydrogel’s water holding capacity from 450% and 480% to 750% and 650% in phosphate buffer solution (PBS) at pH5.5 and pH7.0, respectively. Also PEG enhanced the ability of LMC-PVP hydrogel to retain its moisture from dehydration at body temperature. The morphological study showed PEG developed thick pores wall and reduced the pores size of the hydrogels’ network.

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