Influence of beta-cyclodextrin and chitosan in the formulation of a colon-specific drug delivery system

K. Rehman, Mohd Cairul Iqbal Mohd Amin, S. Muda

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The increase in diseases of the colon underscores the need to develop cost-effective site-directed therapies. We formulated a polysaccharide-based matrix system that could release ibuprofen under conditions simulating those in the colon by employing a wet granulation method. Tablets were prepared in a series of formulations containing a polysaccharide (beta-cyclodextrin and chitosan) matrix system along with ethylcellulose. We characterized physicochemical properties and performed an in vitro drug release assay in the absence and presence of digestive enzymes to assess the ability of the polysaccharides to function as a protective barrier against the upper gastrointestinal environment. Fourier transform infrared spectroscopy studies revealed no chemical interaction between ibuprofen and polysaccharides; however, spectrum analysis suggested the formation of an inclusion complex of beta-cyclodextrin with ibuprofen. The formulations contained 50% ethylcellulose and 50% beta-cyclodextrins (1:1) were proven to be the better formulation that slowly released the drug until 24 h (101.04±0.65% maximum drug release in which 83.08±0.89% drug was released in colonic medium) showed better drug release profiles than the formulations containing chitosan. We conclude that a beta-cyclodextrin drug carrier system may represent an effective approach for treatment of diseases of the colon.

Original languageEnglish
Pages (from-to)657-662
Number of pages6
JournalDrug Research
Volume63
Issue number12
DOIs
Publication statusPublished - Dec 2013

Fingerprint

Drug Delivery Systems
Polysaccharides
Ibuprofen
Colon
beta-Cyclodextrins
Drug Carriers
Chitosan
Fourier Transform Infrared Spectroscopy
Pharmaceutical Preparations
Tablets
Spectrum Analysis
Costs and Cost Analysis
chitosan-beta-cyclodextrin
Enzymes
Therapeutics
Drug Liberation
ethyl cellulose
betadex

Keywords

  • colon drug delivery
  • enzymatic digestion
  • in vitro drug release
  • inclusion complex
  • polysaccharide

ASJC Scopus subject areas

  • Drug Discovery

Cite this

Influence of beta-cyclodextrin and chitosan in the formulation of a colon-specific drug delivery system. / Rehman, K.; Mohd Amin, Mohd Cairul Iqbal; Muda, S.

In: Drug Research, Vol. 63, No. 12, 12.2013, p. 657-662.

Research output: Contribution to journalArticle

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