Induction of myocardial infarction in experimental animals: A review

Syarifah Aisyah Syed Abd Halim, Norzana Abd. Ghafar, Zakiah Jubri, Srijit Das

Research output: Contribution to journalReview article

Abstract

Myocardial Infarction (MI) is a major health problem worldwide. Animal models have been used extensively in scientific research. This was intended to help researchers to understand the underlying pathophysiology of MI, compensatory mechanisms involved and efficacy of treatment. Although, it is difficult to create necrosis similar to those found in human heart, various large and small animals were used to create experimental model of MI. Each of these animals and method of selection offers various advantages and disadvantages in relation to clinical studies. In the present review, we aim to highlight the different methods used to induce MI in experimental animals. These methods may be beneficial for academicians and researchers concerned with the treatment of MI.

Original languageEnglish
JournalJournal of Clinical and Diagnostic Research
Volume12
Issue number11
DOIs
Publication statusPublished - 1 Nov 2018

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Animals
Myocardial Infarction
Research Personnel
Medical problems
Theoretical Models
Necrosis
Animal Models
Research

Keywords

  • Coronary artery
  • Isoprenaline
  • Ligation
  • Myocardial infarction

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Induction of myocardial infarction in experimental animals : A review. / Halim, Syarifah Aisyah Syed Abd; Abd. Ghafar, Norzana; Jubri, Zakiah; Das, Srijit.

In: Journal of Clinical and Diagnostic Research, Vol. 12, No. 11, 01.11.2018.

Research output: Contribution to journalReview article

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