Induced mass change technique for glucose detection in microcantilever- based sensors

Mardhiah Mohd Nor, Badariah Bais, Norazreen Abd Aziz, Rosminazuin Ab Rahim, Burhanuddin Yeop Majlis

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Microcantilever-based glucose sensor is a state-of-art sensor that has been widely investigated for biosensing applications. This work focuses on the preliminary study of correlation of the glucose reaction and the induced force on the microcantilever sensor by measuring the induced mass changes due to the glucose reaction. The induced force is then used to test the fabricated microcantilever sensor for glucose detection. Gold-coated glass slides were used as the immobilization sites for glucose oxidase enzyme. The reaction of the glucose oxidase enzyme and ß-D glucose was observed by injecting 5 mM glucose solution on 0.3 mL immobilized enzyme on three samples. The resulted mass changes, ranging from 151.87 mg to 180. 14 mg for the three samples, indicate a good correlation between the enzyme-glucose reaction and the induced mass change. The induced forces of 0.28 μN to 0.29 μN, converted from the mass changes of the glucose-enzyme reaction, is in a range of interactive force values commonly found in biochemical detection applications.

Original languageEnglish
Title of host publication2012 10th IEEE International Conference on Semiconductor Electronics, ICSE 2012 - Proceedings
Pages340-343
Number of pages4
DOIs
Publication statusPublished - 2012
Event2012 10th IEEE International Conference on Semiconductor Electronics, ICSE 2012 - Kuala Lumpur
Duration: 19 Sep 201221 Sep 2012

Other

Other2012 10th IEEE International Conference on Semiconductor Electronics, ICSE 2012
CityKuala Lumpur
Period19/9/1221/9/12

Fingerprint

Glucose
Enzymes
Sensors
Glucose oxidase
Glucose sensors
Gold
Glass

ASJC Scopus subject areas

  • Hardware and Architecture
  • Electrical and Electronic Engineering

Cite this

Nor, M. M., Bais, B., Abd Aziz, N., Rahim, R. A., & Yeop Majlis, B. (2012). Induced mass change technique for glucose detection in microcantilever- based sensors. In 2012 10th IEEE International Conference on Semiconductor Electronics, ICSE 2012 - Proceedings (pp. 340-343). [6417155] https://doi.org/10.1109/SMElec.2012.6417155

Induced mass change technique for glucose detection in microcantilever- based sensors. / Nor, Mardhiah Mohd; Bais, Badariah; Abd Aziz, Norazreen; Rahim, Rosminazuin Ab; Yeop Majlis, Burhanuddin.

2012 10th IEEE International Conference on Semiconductor Electronics, ICSE 2012 - Proceedings. 2012. p. 340-343 6417155.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nor, MM, Bais, B, Abd Aziz, N, Rahim, RA & Yeop Majlis, B 2012, Induced mass change technique for glucose detection in microcantilever- based sensors. in 2012 10th IEEE International Conference on Semiconductor Electronics, ICSE 2012 - Proceedings., 6417155, pp. 340-343, 2012 10th IEEE International Conference on Semiconductor Electronics, ICSE 2012, Kuala Lumpur, 19/9/12. https://doi.org/10.1109/SMElec.2012.6417155
Nor MM, Bais B, Abd Aziz N, Rahim RA, Yeop Majlis B. Induced mass change technique for glucose detection in microcantilever- based sensors. In 2012 10th IEEE International Conference on Semiconductor Electronics, ICSE 2012 - Proceedings. 2012. p. 340-343. 6417155 https://doi.org/10.1109/SMElec.2012.6417155
Nor, Mardhiah Mohd ; Bais, Badariah ; Abd Aziz, Norazreen ; Rahim, Rosminazuin Ab ; Yeop Majlis, Burhanuddin. / Induced mass change technique for glucose detection in microcantilever- based sensors. 2012 10th IEEE International Conference on Semiconductor Electronics, ICSE 2012 - Proceedings. 2012. pp. 340-343
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