In vivo anti-tumor effects of flavokawain A in 4T1 breast cancer cell-challenged mice

Nadiah Abu, Nurul Elyani Mohamed, Swee Keong Yeap, Kian Lam Lim, M. Nadeem Akhtar, Aimi Jamil Zulfadli, Beh Boon Kee, Mohd Puad Abdullah, Abdul Rahman Omar, Noorjahan Banu Alitheen

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Flavokawain A is a chalcone that can be found in the kava-kava plant (Piper methsyticum) extract. The kava-kava plant has been reported to possess anti-cancer, anti-inflammatory and antinociceptive activities. The state of the immune system, and the inflammatory process play vital roles in the progression of cancer. The immunomodulatary effects and the anti-inflammatory effects of flavokawain A in a breast cancer murine model have not been studied yet. Thus, this study aimed to elucidate the basic mechanism as to how flavokawain A regulates and enhance the immune system as well as impeding the inflammatory process in breast cancer-challenged mice. Based on our study, it is interesting to note that flavokawain A increased the T cell population; both Th1 cells and CTLs, aside from the natural killer cells. The levels of IFN-γ and IL-2 were also elevated in the serum of flavokawain A-treated mice. Apart from that, flavokawain A also decreased the weight and volume of the tumor, and managed to induce apoptosis in them. In terms of inflammation, flavokawain A-treated mice had reduced level of major pro-inflammatory mediators; NO, iNOS, NF-KB, ICAM and COX-2. Overall, flavokawain A has the potential to not only enhance antitumor immunity, but also prevents the inflammatory process in a cancer-prone microenvironment.

Original languageEnglish
Pages (from-to)905-915
Number of pages11
JournalAnti-Cancer Agents in Medicinal Chemistry
Volume15
Issue number7
DOIs
Publication statusPublished - 1 Jul 2015
Externally publishedYes

Fingerprint

Breast Neoplasms
Neoplasms
Kava
Tumor Burden
Immune System Phenomena
Anti-Inflammatory Agents
Piper
Chalcone
Th1 Cells
Tumor Microenvironment
flavokawain A
Natural Killer Cells
Interleukin-2
Immune System
Immunity
Apoptosis
Inflammation
T-Lymphocytes
Serum
Population

Keywords

  • Anti-cancer
  • Chalcone
  • Flavokawain A
  • Immunomodulation

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Cancer Research

Cite this

Abu, N., Mohamed, N. E., Yeap, S. K., Lim, K. L., Nadeem Akhtar, M., Zulfadli, A. J., ... Alitheen, N. B. (2015). In vivo anti-tumor effects of flavokawain A in 4T1 breast cancer cell-challenged mice. Anti-Cancer Agents in Medicinal Chemistry, 15(7), 905-915. https://doi.org/10.2174/187152061507150713111557

In vivo anti-tumor effects of flavokawain A in 4T1 breast cancer cell-challenged mice. / Abu, Nadiah; Mohamed, Nurul Elyani; Yeap, Swee Keong; Lim, Kian Lam; Nadeem Akhtar, M.; Zulfadli, Aimi Jamil; Kee, Beh Boon; Abdullah, Mohd Puad; Omar, Abdul Rahman; Alitheen, Noorjahan Banu.

In: Anti-Cancer Agents in Medicinal Chemistry, Vol. 15, No. 7, 01.07.2015, p. 905-915.

Research output: Contribution to journalArticle

Abu, N, Mohamed, NE, Yeap, SK, Lim, KL, Nadeem Akhtar, M, Zulfadli, AJ, Kee, BB, Abdullah, MP, Omar, AR & Alitheen, NB 2015, 'In vivo anti-tumor effects of flavokawain A in 4T1 breast cancer cell-challenged mice', Anti-Cancer Agents in Medicinal Chemistry, vol. 15, no. 7, pp. 905-915. https://doi.org/10.2174/187152061507150713111557
Abu, Nadiah ; Mohamed, Nurul Elyani ; Yeap, Swee Keong ; Lim, Kian Lam ; Nadeem Akhtar, M. ; Zulfadli, Aimi Jamil ; Kee, Beh Boon ; Abdullah, Mohd Puad ; Omar, Abdul Rahman ; Alitheen, Noorjahan Banu. / In vivo anti-tumor effects of flavokawain A in 4T1 breast cancer cell-challenged mice. In: Anti-Cancer Agents in Medicinal Chemistry. 2015 ; Vol. 15, No. 7. pp. 905-915.
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