In vitro inhibitory effect of rubraxanthone isolated from Garcinia parvifolia on platelet-activating factor receptor binding

Ibrahim Jantan, Mazura Md Pisar, Muhammad Sum Idris, M. Taher, Rasadah Mat Ali

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Rubraxanthone and isocowanol isolated from Garcinia parvifolia Miq. were investigated for their inhibitory effects on platelet-activating factor (PAF) binding to rabbit platelets using 3H-PAF as a ligand. Rubraxanthone showed a strong inhibition with IC50 value of 18.2 μM. The IC50 values of macluraxanthone, 6-deoxyjacareubin, 2-(3-methylbut-2-enyl)-1,3,5-trihydroxyxanthone, 2-(3-methylbut-2-enyl)-1,3,5,6-tetrahydroxyxanthone and 1,3,5-trihydroxy-6,6′-dimethylpyrano(2′,3′:6,7)-4-(1,1- dimethylprop-2-enyl)-xanthone were also determined for comparison. In the course of our study on structure-activity relationship of xanthones, the results revealed that a geranyl group substituted at C-8 was beneficial to the binding while a hydroxylated prenyl group at C-4 resulted in a significant loss in binding to the PAF receptor.

Original languageEnglish
Pages (from-to)1133-1134
Number of pages2
JournalPlanta Medica
Volume68
Issue number12
DOIs
Publication statusPublished - 1 Dec 2002

Fingerprint

Garcinia
platelet-activating factor
Platelet Activating Factor
Inhibitory Concentration 50
Xanthones
receptors
inhibitory concentration 50
Structure-Activity Relationship
Platelets
xanthone
xanthones
Blood Platelets
structure-activity relationships
Rabbits
Ligands
rabbits
platelet activating factor receptor
rubraxanthone
In Vitro Techniques

ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

In vitro inhibitory effect of rubraxanthone isolated from Garcinia parvifolia on platelet-activating factor receptor binding. / Jantan, Ibrahim; Pisar, Mazura Md; Idris, Muhammad Sum; Taher, M.; Ali, Rasadah Mat.

In: Planta Medica, Vol. 68, No. 12, 01.12.2002, p. 1133-1134.

Research output: Contribution to journalArticle

Jantan, Ibrahim ; Pisar, Mazura Md ; Idris, Muhammad Sum ; Taher, M. ; Ali, Rasadah Mat. / In vitro inhibitory effect of rubraxanthone isolated from Garcinia parvifolia on platelet-activating factor receptor binding. In: Planta Medica. 2002 ; Vol. 68, No. 12. pp. 1133-1134.
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