In vitro evaluation of anticancer effect and neurotoxicity of Styrylpyrone derivative (SPD)

Chee Wai Yip, Yasuo Nagaoka, Norefrina Shafinaz Md Nor, Nazlina Ibrahim

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

The increasing number of death due to cancer emphasizes the need of novel anticancer agents. Styrylpyrone derivative (SPD) was previously found to have potential anticancer action towards many types of cancer. Some of the SPD-anticancer mechanisms were elucidated as induction of cancer cell apoptosis. However, more understanding on cancer cell type specific action of SPD-anticancer effects needs to be evaluated. HCT-116 cell line, a type of human colon carcinoma, was used to study SPD-anticancer effect. It was found that SPD concentration as low as 0.25 μM was able to inhibit 80% growth of cancer cells. IC50 value of SPD for HCT-116 was found to be 0.038 μM. Neurotoxicity test, carried out to determine the adverse effect of SPD towards nerve cells, gives CC50 value as 4.88 μM, thus concluded it to be a neurotoxic compound.

Original languageEnglish
Title of host publication2016 UKM FST Postgraduate Colloquium: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2016 Postgraduate Colloquium
PublisherAmerican Institute of Physics Inc.
Volume1784
ISBN (Electronic)9780735414464
DOIs
Publication statusPublished - 17 Nov 2016
Event2016 Postgraduate Colloquium of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology, UKM FST 2016 - Selangor, Malaysia
Duration: 13 Apr 201614 Apr 2016

Other

Other2016 Postgraduate Colloquium of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology, UKM FST 2016
CountryMalaysia
CitySelangor
Period13/4/1614/4/16

Fingerprint

cancer
evaluation
apoptosis
nerves
cultured cells
death
induction
cells

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Yip, C. W., Nagaoka, Y., Md Nor, N. S., & Ibrahim, N. (2016). In vitro evaluation of anticancer effect and neurotoxicity of Styrylpyrone derivative (SPD). In 2016 UKM FST Postgraduate Colloquium: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2016 Postgraduate Colloquium (Vol. 1784). [020013] American Institute of Physics Inc.. https://doi.org/10.1063/1.4966723

In vitro evaluation of anticancer effect and neurotoxicity of Styrylpyrone derivative (SPD). / Yip, Chee Wai; Nagaoka, Yasuo; Md Nor, Norefrina Shafinaz; Ibrahim, Nazlina.

2016 UKM FST Postgraduate Colloquium: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2016 Postgraduate Colloquium. Vol. 1784 American Institute of Physics Inc., 2016. 020013.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Yip, CW, Nagaoka, Y, Md Nor, NS & Ibrahim, N 2016, In vitro evaluation of anticancer effect and neurotoxicity of Styrylpyrone derivative (SPD). in 2016 UKM FST Postgraduate Colloquium: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2016 Postgraduate Colloquium. vol. 1784, 020013, American Institute of Physics Inc., 2016 Postgraduate Colloquium of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology, UKM FST 2016, Selangor, Malaysia, 13/4/16. https://doi.org/10.1063/1.4966723
Yip CW, Nagaoka Y, Md Nor NS, Ibrahim N. In vitro evaluation of anticancer effect and neurotoxicity of Styrylpyrone derivative (SPD). In 2016 UKM FST Postgraduate Colloquium: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2016 Postgraduate Colloquium. Vol. 1784. American Institute of Physics Inc. 2016. 020013 https://doi.org/10.1063/1.4966723
Yip, Chee Wai ; Nagaoka, Yasuo ; Md Nor, Norefrina Shafinaz ; Ibrahim, Nazlina. / In vitro evaluation of anticancer effect and neurotoxicity of Styrylpyrone derivative (SPD). 2016 UKM FST Postgraduate Colloquium: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2016 Postgraduate Colloquium. Vol. 1784 American Institute of Physics Inc., 2016.
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