In vitro development of autologous tissue engineered human articular neocartilage for orthopaedic surgery.

O. C. Samsudin, B. S. Aminuddin, S. Munirah, Chua Kien Hui, N. H. Fuzina, M. R. Isa, Azmi Baharudin, Md. Yusoff Badrul Akmal Hisham, Ruszymah Idrus

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Treatment of articular cartilage lesions remains a clinical challenge. The uses of prosthetic joint replace allograft and/or autograft transplant carry a risk of complications due to infection, loosening of its component, immunological rejection and morbidity at the donor site. There has been an increasing interest in the management of cartilage damages, owing to the introduction of new therapeutic options. Tissue engineering as a method for tissue restoration begins to provide a potential alternative therapy for autologous grafts transplantations. We aimed to evaluate how well a tissue engineered neocartilage implant, consist of human articular chondrocytes cultured with the presence of autologous serum and mixed in a fresh fibrin derived from patient, would perform in subcutaneous implantation in athymic mice.

Original languageEnglish
Pages (from-to)15-16
Number of pages2
JournalThe Medical journal of Malaysia
Volume59 Suppl B
Publication statusPublished - May 2004

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Orthopedics
Joints
Transplants
Autologous Transplantation
Autografts
Articular Cartilage
Tissue Engineering
Complementary Therapies
Chondrocytes
Fibrin
Nude Mice
Cartilage
Allografts
Tissue Donors
Morbidity
Therapeutics
Infection
Serum
In Vitro Techniques

ASJC Scopus subject areas

  • Medicine(all)

Cite this

In vitro development of autologous tissue engineered human articular neocartilage for orthopaedic surgery. / Samsudin, O. C.; Aminuddin, B. S.; Munirah, S.; Kien Hui, Chua; Fuzina, N. H.; Isa, M. R.; Baharudin, Azmi; Badrul Akmal Hisham, Md. Yusoff; Idrus, Ruszymah.

In: The Medical journal of Malaysia, Vol. 59 Suppl B, 05.2004, p. 15-16.

Research output: Contribution to journalArticle

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