In-vitro cytotoxicity studies of vanadyl complexes with hydroxamic acid series

S. N M Shotor, K. Kassim, H. Bahron, A. M. Tajuddin, F. Z. Yusof, C. J. Marmion, N. F. Rajab

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Two vanadium(IV) complexes of hydroxamic acid derivatives namely benzohydroxamic acid (BHA) and salicylhydroxamic acid (SHA) are synthesized and characterized using elemental analysis, infrared spectroscopy and 1H NMR spectroscopy. Through infrared investigation, it is intimated that the hydroxamic acids coordinate to the metal centers as O,O bis-bidentate ligands, each acting as singly deprotonated hydroxamato moieties. Upon in-vitro cytoxicity investigation on liver cell-lines using MTT assay, all the ligands are revealed to be non-toxic whereas the complexes showed very much enhanced toxicity with the lowest cell viability of 17.8% after a 72-hour exposure to the compounds.

Original languageEnglish
Title of host publicationCSSR 2010 - 2010 International Conference on Science and Social Research
Pages1283-1286
Number of pages4
DOIs
Publication statusPublished - 2010
Event2010 International Conference on Science and Social Research, CSSR 2010 - Kuala Lumpur
Duration: 5 Dec 20107 Dec 2010

Other

Other2010 International Conference on Science and Social Research, CSSR 2010
CityKuala Lumpur
Period5/12/107/12/10

Keywords

  • Hydroxamic acids
  • in-vitro cytotoxicity
  • liver cell lines
  • vanadyl complexes

ASJC Scopus subject areas

  • Social Sciences(all)

Cite this

Shotor, S. N. M., Kassim, K., Bahron, H., Tajuddin, A. M., Yusof, F. Z., Marmion, C. J., & Rajab, N. F. (2010). In-vitro cytotoxicity studies of vanadyl complexes with hydroxamic acid series. In CSSR 2010 - 2010 International Conference on Science and Social Research (pp. 1283-1286). [5773735] https://doi.org/10.1109/CSSR.2010.5773735

In-vitro cytotoxicity studies of vanadyl complexes with hydroxamic acid series. / Shotor, S. N M; Kassim, K.; Bahron, H.; Tajuddin, A. M.; Yusof, F. Z.; Marmion, C. J.; Rajab, N. F.

CSSR 2010 - 2010 International Conference on Science and Social Research. 2010. p. 1283-1286 5773735.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Shotor, SNM, Kassim, K, Bahron, H, Tajuddin, AM, Yusof, FZ, Marmion, CJ & Rajab, NF 2010, In-vitro cytotoxicity studies of vanadyl complexes with hydroxamic acid series. in CSSR 2010 - 2010 International Conference on Science and Social Research., 5773735, pp. 1283-1286, 2010 International Conference on Science and Social Research, CSSR 2010, Kuala Lumpur, 5/12/10. https://doi.org/10.1109/CSSR.2010.5773735
Shotor SNM, Kassim K, Bahron H, Tajuddin AM, Yusof FZ, Marmion CJ et al. In-vitro cytotoxicity studies of vanadyl complexes with hydroxamic acid series. In CSSR 2010 - 2010 International Conference on Science and Social Research. 2010. p. 1283-1286. 5773735 https://doi.org/10.1109/CSSR.2010.5773735
Shotor, S. N M ; Kassim, K. ; Bahron, H. ; Tajuddin, A. M. ; Yusof, F. Z. ; Marmion, C. J. ; Rajab, N. F. / In-vitro cytotoxicity studies of vanadyl complexes with hydroxamic acid series. CSSR 2010 - 2010 International Conference on Science and Social Research. 2010. pp. 1283-1286
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AU - Yusof, F. Z.

AU - Marmion, C. J.

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AB - Two vanadium(IV) complexes of hydroxamic acid derivatives namely benzohydroxamic acid (BHA) and salicylhydroxamic acid (SHA) are synthesized and characterized using elemental analysis, infrared spectroscopy and 1H NMR spectroscopy. Through infrared investigation, it is intimated that the hydroxamic acids coordinate to the metal centers as O,O bis-bidentate ligands, each acting as singly deprotonated hydroxamato moieties. Upon in-vitro cytoxicity investigation on liver cell-lines using MTT assay, all the ligands are revealed to be non-toxic whereas the complexes showed very much enhanced toxicity with the lowest cell viability of 17.8% after a 72-hour exposure to the compounds.

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