In vitro antidiabetic activity of various crude extracts of Boletus variipes

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Diabetes mellitus is a complex metabolic disease that progressively spread worldwide and difficult to treat due to various physical and metabolic complications. Current treatment using synthetic drugs has lead to various undesirable side effects. Here we determined the effect of Boletus variipes extracts on diabetes related enzymes. In this study, hot water, cold water and methanol extracts of B. variipes were utilized in order to assess their in vitro antidiabetic activity by measuring the effect on α-amylase and α-glucosidase enzyme. Hot water extract possessed the highest inhibition activity of α-amylase and α-glucosidase in a concentration dependent manner with the IC50 value 87 mg/mL and 89 mg/mL respectively. The methanol extract also showed inhibition activity of α-amylase and α-glucosidase but significantly lower than the hot water extract. Whereas cold water extract did not show any inhibition activity towards both the enzymes. Therefore, it is hypothesized that the hot water extract of Boletus variipes contains bioactive compound that can inhibit alpha-amylase and alpha-glucosidase enzyme activity.

Original languageEnglish
Title of host publication2015 UKM FST Postgraduate Colloquium: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2015 Postgraduate Colloquium
PublisherAmerican Institute of Physics Inc.
Volume1678
ISBN (Electronic)9780735413252
DOIs
Publication statusPublished - 25 Sep 2015
Event2015 Postgraduate Colloquium of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology, UKM FST 2015 - Selangor, Malaysia
Duration: 15 Apr 201516 Apr 2015

Other

Other2015 Postgraduate Colloquium of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology, UKM FST 2015
CountryMalaysia
CitySelangor
Period15/4/1516/4/15

Fingerprint

enzymes
cold water
water
metabolic diseases
methyl alcohol
diabetes mellitus
enzyme activity
activity (biology)
drugs

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Muniandy, S., Sa`Ariwijaya, M. S. F., Daud, F., & Senafi, S. (2015). In vitro antidiabetic activity of various crude extracts of Boletus variipes. In 2015 UKM FST Postgraduate Colloquium: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2015 Postgraduate Colloquium (Vol. 1678). [030022] American Institute of Physics Inc.. https://doi.org/10.1063/1.4931243

In vitro antidiabetic activity of various crude extracts of Boletus variipes. / Muniandy, Sutha; Sa`Ariwijaya, Mohd Shazrul Fazry; Daud, Fauzi; Senafi, Sahidan.

2015 UKM FST Postgraduate Colloquium: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2015 Postgraduate Colloquium. Vol. 1678 American Institute of Physics Inc., 2015. 030022.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Muniandy, S, Sa`Ariwijaya, MSF, Daud, F & Senafi, S 2015, In vitro antidiabetic activity of various crude extracts of Boletus variipes. in 2015 UKM FST Postgraduate Colloquium: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2015 Postgraduate Colloquium. vol. 1678, 030022, American Institute of Physics Inc., 2015 Postgraduate Colloquium of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology, UKM FST 2015, Selangor, Malaysia, 15/4/15. https://doi.org/10.1063/1.4931243
Muniandy S, Sa`Ariwijaya MSF, Daud F, Senafi S. In vitro antidiabetic activity of various crude extracts of Boletus variipes. In 2015 UKM FST Postgraduate Colloquium: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2015 Postgraduate Colloquium. Vol. 1678. American Institute of Physics Inc. 2015. 030022 https://doi.org/10.1063/1.4931243
Muniandy, Sutha ; Sa`Ariwijaya, Mohd Shazrul Fazry ; Daud, Fauzi ; Senafi, Sahidan. / In vitro antidiabetic activity of various crude extracts of Boletus variipes. 2015 UKM FST Postgraduate Colloquium: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2015 Postgraduate Colloquium. Vol. 1678 American Institute of Physics Inc., 2015.
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