In vitro antiamoebic and antiplasmodial activities of alkaloids isolated from Alstonia angustifolia roots

C. W. Wright, D. Allen, Y. Cai, J. D. Phillipson, I. M. Said, G. C. Kirby, D. C. Warhurst

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Nine alkaloids from Alstonia angustifolia have been assessed for antiprotozoal activities against Entamoeba histolytica and Plasmodium falciparum in vitro. Three dimeric alkaloids, macrocarpamine, macralstonine acetate (semisynthetic) and villastonine were found to possess significant activity against both protozoans, but were 4-8 times less potent than emetine against E. histolytica and 15-50 times less potent than chloroquine against P. falciparum. The monomeric alkaloids, alstonerine, alstophylline, 11-methoxyakuammicine, norfluorocurarine, pleiocarpamine and vincamajine were all considerably less active than the dimers: macralstonine base was found to be inactive.

Original languageEnglish
Pages (from-to)121-124
Number of pages4
JournalPhytotherapy Research
Volume6
Issue number3
DOIs
Publication statusPublished - 1992
Externally publishedYes

Fingerprint

Alstonia
Alkaloids
Entamoeba histolytica
Plasmodium falciparum
Emetine
Chloroquine
Dimers
Acetates
In Vitro Techniques
macralstonine

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Wright, C. W., Allen, D., Cai, Y., Phillipson, J. D., Said, I. M., Kirby, G. C., & Warhurst, D. C. (1992). In vitro antiamoebic and antiplasmodial activities of alkaloids isolated from Alstonia angustifolia roots. Phytotherapy Research, 6(3), 121-124. https://doi.org/10.1002/ptr.2650060303

In vitro antiamoebic and antiplasmodial activities of alkaloids isolated from Alstonia angustifolia roots. / Wright, C. W.; Allen, D.; Cai, Y.; Phillipson, J. D.; Said, I. M.; Kirby, G. C.; Warhurst, D. C.

In: Phytotherapy Research, Vol. 6, No. 3, 1992, p. 121-124.

Research output: Contribution to journalArticle

Wright, CW, Allen, D, Cai, Y, Phillipson, JD, Said, IM, Kirby, GC & Warhurst, DC 1992, 'In vitro antiamoebic and antiplasmodial activities of alkaloids isolated from Alstonia angustifolia roots', Phytotherapy Research, vol. 6, no. 3, pp. 121-124. https://doi.org/10.1002/ptr.2650060303
Wright, C. W. ; Allen, D. ; Cai, Y. ; Phillipson, J. D. ; Said, I. M. ; Kirby, G. C. ; Warhurst, D. C. / In vitro antiamoebic and antiplasmodial activities of alkaloids isolated from Alstonia angustifolia roots. In: Phytotherapy Research. 1992 ; Vol. 6, No. 3. pp. 121-124.
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