In vitro anti-malarial activity of Andrographis paniculata (Acanthaceae)

Mohamed Kamel Abdul Ghani, M. J Siti Najila, S. I Syed Zahir, A. Noor Rain, Lokman Hakim, I. Zakiah, Khozirah, Azizol

Research output: Contribution to journalArticle

Abstract

Introduction: Malaria continues to be a major public health problem in most countries of the tropical world and its control is becoming increasingly difficult. The emergence of Plasmodium falciparum resistance to widely used anti-malarial drugs such as chloroquine has made malaria control and treatment much more difficult. To overcome this growing problem, attention has been focused on medicinal plants, in the hope that they can provide new and novel anti-malarial agents. Objective: In this preliminary study, a plant from Malaysia, Andrographis paniculata (Acanthaceae) was selected based on its traditional values and claims, and screened for anti-malarial activity towards Plasmodium falciparum. Materials and Methods: Two strains of Plasmodium falciparum, the chloroquine resistant, Gombak A and the sensitive strain, D10 were screened for anti-malarial activity in vitro using the lactate dehydrogenase (LDH) assay. Results: The crude extract of Andrographis paniculata showed reasonably good activities towards the target strains. It inhibited the sensitive strain at IC50 of 45.74 μ g/ml and for the resistant strain at IC50 of 65.06 μ g/ml. Conclusion: Andrographis paniculata has the potential to be a source of new anti-malarial drug for the future.

Original languageEnglish
Pages (from-to)43-46
Number of pages4
JournalInternational Medical Journal
Volume10
Issue number1
Publication statusPublished - Mar 2003

Fingerprint

Andrographis
Acanthaceae
Antimalarials
Plasmodium falciparum
Chloroquine
Inhibitory Concentration 50
Malaria
Malaysia
Medicinal Plants
Complex Mixtures
L-Lactate Dehydrogenase
Pharmaceutical Preparations
Public Health
In Vitro Techniques

Keywords

  • Andrographis paniculata
  • In vitro anti-malarial activity
  • Lactate dehydrogenase (LDH) assay
  • Medicinal plants
  • Plasmodium falciparum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Abdul Ghani, M. K., Najila, M. J. S., Zahir, S. I. S., Rain, A. N., Hakim, L., Zakiah, I., ... Azizol (2003). In vitro anti-malarial activity of Andrographis paniculata (Acanthaceae). International Medical Journal, 10(1), 43-46.

In vitro anti-malarial activity of Andrographis paniculata (Acanthaceae). / Abdul Ghani, Mohamed Kamel; Najila, M. J Siti; Zahir, S. I Syed; Rain, A. Noor; Hakim, Lokman; Zakiah, I.; Khozirah; Azizol.

In: International Medical Journal, Vol. 10, No. 1, 03.2003, p. 43-46.

Research output: Contribution to journalArticle

Abdul Ghani, MK, Najila, MJS, Zahir, SIS, Rain, AN, Hakim, L, Zakiah, I, Khozirah & Azizol 2003, 'In vitro anti-malarial activity of Andrographis paniculata (Acanthaceae)', International Medical Journal, vol. 10, no. 1, pp. 43-46.
Abdul Ghani MK, Najila MJS, Zahir SIS, Rain AN, Hakim L, Zakiah I et al. In vitro anti-malarial activity of Andrographis paniculata (Acanthaceae). International Medical Journal. 2003 Mar;10(1):43-46.
Abdul Ghani, Mohamed Kamel ; Najila, M. J Siti ; Zahir, S. I Syed ; Rain, A. Noor ; Hakim, Lokman ; Zakiah, I. ; Khozirah ; Azizol. / In vitro anti-malarial activity of Andrographis paniculata (Acanthaceae). In: International Medical Journal. 2003 ; Vol. 10, No. 1. pp. 43-46.
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