In-vitro activity of quinupristin/dalfopristin, levofloxacin and moxifloxacin against fusidic acid and rifampicin-resistant strains of methicillin-resistant Staphylcoccus aureus (MRSA) from Malaysian hospitals

Ahmad Norazah, V. K E Lim, M. Y. Rohani, Mohamed Kamel Abdul Ghani

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The in-vitro susceptibility of quinupristin/dalfopristin, levofloxacin and moxifloxacin against methicillin-resistant Staphylococcus aureus (MRSA) strains, which are also resistant to fusidic acid and rifampicin were carried out to determine whether these antibiotics can be used as an alternative treatment for multiply resistant MRSA strains. The minimum inhibitory concentrations (MIC) of these antibiotics were determined by E-test. Quinupristin/dalfopristin had good activity (MIC90 = 1mg/L) against these strains while most of the strains showed intermediate resistance to moxifloxacin with MIC90 = 2mg/L). However, more than 90% of these strains were resistant to levofloxacin with the MICs that ranged from 8 mg/L to 16 mg/L with the majority inhibited at 8 mg/L.

Original languageEnglish
Pages (from-to)411-415
Number of pages5
JournalMedical Journal of Malaysia
Volume60
Issue number4
Publication statusPublished - 2005

Fingerprint

Fusidic Acid
Levofloxacin
Methicillin Resistance
Rifampin
Anti-Bacterial Agents
Microbial Sensitivity Tests
Methicillin-Resistant Staphylococcus aureus
moxifloxacin
In Vitro Techniques
quinupristin-dalfopristin

Keywords

  • Levofloxacin
  • Moxifloxacin · MIC · MRSA
  • Quinupristin/dalfopristin

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "In-vitro activity of quinupristin/dalfopristin, levofloxacin and moxifloxacin against fusidic acid and rifampicin-resistant strains of methicillin-resistant Staphylcoccus aureus (MRSA) from Malaysian hospitals",
abstract = "The in-vitro susceptibility of quinupristin/dalfopristin, levofloxacin and moxifloxacin against methicillin-resistant Staphylococcus aureus (MRSA) strains, which are also resistant to fusidic acid and rifampicin were carried out to determine whether these antibiotics can be used as an alternative treatment for multiply resistant MRSA strains. The minimum inhibitory concentrations (MIC) of these antibiotics were determined by E-test. Quinupristin/dalfopristin had good activity (MIC90 = 1mg/L) against these strains while most of the strains showed intermediate resistance to moxifloxacin with MIC90 = 2mg/L). However, more than 90{\%} of these strains were resistant to levofloxacin with the MICs that ranged from 8 mg/L to 16 mg/L with the majority inhibited at 8 mg/L.",
keywords = "Levofloxacin, Moxifloxacin · MIC · MRSA, Quinupristin/dalfopristin",
author = "Ahmad Norazah and Lim, {V. K E} and Rohani, {M. Y.} and {Abdul Ghani}, {Mohamed Kamel}",
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T1 - In-vitro activity of quinupristin/dalfopristin, levofloxacin and moxifloxacin against fusidic acid and rifampicin-resistant strains of methicillin-resistant Staphylcoccus aureus (MRSA) from Malaysian hospitals

AU - Norazah, Ahmad

AU - Lim, V. K E

AU - Rohani, M. Y.

AU - Abdul Ghani, Mohamed Kamel

PY - 2005

Y1 - 2005

N2 - The in-vitro susceptibility of quinupristin/dalfopristin, levofloxacin and moxifloxacin against methicillin-resistant Staphylococcus aureus (MRSA) strains, which are also resistant to fusidic acid and rifampicin were carried out to determine whether these antibiotics can be used as an alternative treatment for multiply resistant MRSA strains. The minimum inhibitory concentrations (MIC) of these antibiotics were determined by E-test. Quinupristin/dalfopristin had good activity (MIC90 = 1mg/L) against these strains while most of the strains showed intermediate resistance to moxifloxacin with MIC90 = 2mg/L). However, more than 90% of these strains were resistant to levofloxacin with the MICs that ranged from 8 mg/L to 16 mg/L with the majority inhibited at 8 mg/L.

AB - The in-vitro susceptibility of quinupristin/dalfopristin, levofloxacin and moxifloxacin against methicillin-resistant Staphylococcus aureus (MRSA) strains, which are also resistant to fusidic acid and rifampicin were carried out to determine whether these antibiotics can be used as an alternative treatment for multiply resistant MRSA strains. The minimum inhibitory concentrations (MIC) of these antibiotics were determined by E-test. Quinupristin/dalfopristin had good activity (MIC90 = 1mg/L) against these strains while most of the strains showed intermediate resistance to moxifloxacin with MIC90 = 2mg/L). However, more than 90% of these strains were resistant to levofloxacin with the MICs that ranged from 8 mg/L to 16 mg/L with the majority inhibited at 8 mg/L.

KW - Levofloxacin

KW - Moxifloxacin · MIC · MRSA

KW - Quinupristin/dalfopristin

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