In silico characterisation of the glaciozyma antarctica genome

Mining the molecular chaperones

Y. Nur Athirah, Farah Diba Abu Bakar, R. M. Illias, N. M. Mahadi, Abdul Munir Abd. Murad

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Glaciozyma antarctica is a psychrophilic yeast isolated from the Antarctic sea ice. In this study, we performed a de novo characterisation of molecular chaperones from G. antarctica genome datasets. A total of 7857 genes that code for various types of proteins have been predicted from the G. antarctica genome sequence. From these genes, we identified 89 possible molecular chaperones that matched known molecular chaperones from other organisms available in various databases such as Uniprot, Gene Ontology, cpnDB and NCBI. For an in-depth analysis of molecular functions, we used homologous clustering to transfer knowledge from unknown to known functions using Cluster Analysis of Sequences (CLANS) bioinformatics software. The results reveal 12 major groups of chaperones that contribute to the cold-adaptation mechanism through their molecular function, biological processes and cellular components. The findings lay the foundation for future functional genomics studies on this organism and shed light on how lower eukaryotic cells respond to low temperature.

Original languageEnglish
Pages (from-to)161-165
Number of pages5
JournalMalaysian Applied Biology
Volume44
Issue number1
Publication statusPublished - 2015

Fingerprint

molecular chaperones
Molecular Chaperones
Computer Simulation
Antarctica
Genome
Cluster Analysis
Biological Phenomena
Ice Cover
Gene Ontology
genome
genes
organisms
Eukaryotic Cells
Genomics
Computational Biology
bioinformatics
Genes
eukaryotic cells
cluster analysis
ice

Keywords

  • Clustering analysis
  • Functional genomics
  • Glaciozyma antarctica
  • Molecular chaperones

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

In silico characterisation of the glaciozyma antarctica genome : Mining the molecular chaperones. / Nur Athirah, Y.; Abu Bakar, Farah Diba; Illias, R. M.; Mahadi, N. M.; Abd. Murad, Abdul Munir.

In: Malaysian Applied Biology, Vol. 44, No. 1, 2015, p. 161-165.

Research output: Contribution to journalArticle

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