Improving the synthesis of spiropyran derivatives using microwave irradiation method

Research output: Contribution to journalArticle

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Abstract

A solvent free synthesis of spiropyran derivatives has been developed from the condensation of indoline and salicylaldehyde using a microwave irradiation method. This method starts from readily available starting materials and provides biologically interesting products. The microwave irradiation method was remarkably successful and gave spiropyran derivatives in higher yield (72-99%) with a much shorter reaction time (10-15 min) compared to the conventional heating method. The chemical structures of the compounds prepared were characterized through IR, 1H NMR and 13C NMR spectral data.

Original languageEnglish
Pages (from-to)1017-1024
Number of pages8
JournalHeterocycles
Volume89
Issue number4
DOIs
Publication statusPublished - 2014

Fingerprint

Microwave irradiation
Microwaves
Nuclear magnetic resonance
Derivatives
Condensation
Heating
spiropyran
indoline
salicylaldehyde

ASJC Scopus subject areas

  • Analytical Chemistry
  • Organic Chemistry
  • Pharmacology

Cite this

Improving the synthesis of spiropyran derivatives using microwave irradiation method. / Rohadi, Atisya; Hasbullah, Siti Aishah; Mat Lazim, Mohamad Azwani Shah; Nordin, Rumaisa.

In: Heterocycles, Vol. 89, No. 4, 2014, p. 1017-1024.

Research output: Contribution to journalArticle

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