Improvement of metabolic parameters in healthy older adult men following a fasting calorie restriction intervention

Nur Islami Mohd Fahmi Teng, Suzana Shahar, Nor Fadilah Rajab, Zahara Abdul Manaf, Mohamad Hanapi Johari, Wan Zurinah Wan Ngah

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective: Calorie restriction and intermittent fasting are two dietary interventions that can improve aging. Religious fasting also suggested having similar benefit; however, such studies are still scarce. Thus, this study aimed to determine the effect of fasting calorie restriction (FCR) on metabolic parameters and DNA damage among healthy older adult men. Methods: A randomized controlled study was done on men, aged 50-70 years in Klang Valley, Malaysia. Subjects were divided into two groups; FCR (reduction of 300-500kcal/d combined with 2 days/week of Muslim Sunnah Fasting) and control. Assessment was ascertained at three time point; baseline, weeks 6 and 12. Blood samples were analyzed for lipid profile, DNA damage and malondialdehyde (MDA). Results: The FCR group reduced their energy intake for approximately 18% upon completion of the study. A significant interaction effect was found in body weight, body mass index, fat percentage, fat mass, blood pressure, total cholesterol, low-density lipoprotein cholesterol and the ratio of total cholesterol/high-density lipoprotein cholesterol (p<0.05). A significant improvement (p<0.001) in total DNA rejoining cells and MDA (p<0.05) was also observed in the FCR group. Conclusion: FCR improved metabolic parameters and DNA damage in healthy older adult men. Therefore, there is a need to further examine the mechanism of FCR.

Original languageEnglish
Pages (from-to)177-183
Number of pages7
JournalAging Male
Volume16
Issue number4
DOIs
Publication statusPublished - Dec 2013

Fingerprint

Fasting
DNA Damage
Malondialdehyde
Fats
Cholesterol
Islam
Malaysia
Energy Intake
LDL Cholesterol
HDL Cholesterol
Body Mass Index
Body Weight
Blood Pressure
Lipids
DNA

Keywords

  • Aging
  • Calorie restriction
  • Fasting
  • Nutrition
  • Religious fasting

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Improvement of metabolic parameters in healthy older adult men following a fasting calorie restriction intervention. / Teng, Nur Islami Mohd Fahmi; Shahar, Suzana; Rajab, Nor Fadilah; Abdul Manaf, Zahara; Johari, Mohamad Hanapi; Ngah, Wan Zurinah Wan.

In: Aging Male, Vol. 16, No. 4, 12.2013, p. 177-183.

Research output: Contribution to journalArticle

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AU - Johari, Mohamad Hanapi

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