Improvement of gastric lesion index after treatment with palm vitamin E compared to ranitidine

Kamsiah Jaarin, Renuvathani, M. I. Nafeeza, M. T. Gapor

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The effect of palm vitamin E on the healing of ethanol-induced gastric lesion was compared with ranitidine. Fifty-six male rats of Sprague-Dawley species (200-250 gm of weight) were randomly divided into three groups (n=14). Gastric mucosal injury was induced by orogastric tube administration of 0.5 ml 100% ethanol. Immediately after induction, Group I (k) rats was fed with a normal diet (control), group II (p) was fed palm vitamin E enriched diet (150 mg/kg food), Group III (r) was treated with ranitidine 30 mg/kg body weight intraperitonally for 1 week. The rate of gastric healing was faster in the palm vitamin E treated group as shown by a lower mean ulcer index. The healing was accompanied by a lower gastric tissue content of MDA. The effect was seen as early as the first week of treatment. After 1 week of treatment ranitidine did not show any effect on healing or gastric acid concentration. The healing effect of palm vitamin E is probably due to its effect on lipid peroxidation as shown by the lower gastric MDA content.

Original languageEnglish
Pages (from-to)159-164
Number of pages6
JournalAsia Pacific Journal of Pharmacology
Volume13
Issue number4
Publication statusPublished - 1998

Fingerprint

Ranitidine
Vitamin E
Stomach
Gastrointestinal Contents
Ethanol
Diet
Gastric Acid
Lipid Peroxidation
Ulcer
Sprague Dawley Rats
Body Weight
Weights and Measures
Food
Control Groups
Wounds and Injuries

Keywords

  • Ethanol
  • Gastric lesion
  • Palm vitamin E
  • Ranitidine
  • Rat

ASJC Scopus subject areas

  • Pharmacology

Cite this

Improvement of gastric lesion index after treatment with palm vitamin E compared to ranitidine. / Jaarin, Kamsiah; Renuvathani; Nafeeza, M. I.; Gapor, M. T.

In: Asia Pacific Journal of Pharmacology, Vol. 13, No. 4, 1998, p. 159-164.

Research output: Contribution to journalArticle

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