Improvement in binge eating in non-diabetic obese individuals after 3 months of treatment with liraglutide - A pilot study

Sarah Anne Robert, Abdul Ghani Rohana, Shamsul Azhar Shah, Karuthan Chinna, Wan Nazaimoon Wan Mohamud, Nor Azmi Kamaruddin

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We examined the effects of liraglutide, a glucagon-like peptide-1 analogue on appetite and plasma ghrelin in non-diabetic obese participants with subclinical binge eating (BE). Forty-four obese BE participants (mean age: 34 ± 9 years, BMI: 35.9 ± 4.2 kg/m<sup>2</sup>) were randomly assigned to intervention or control groups for 12 weeks. All participants received standard advice for diet and exercise. Binge eating score, ghrelin levels and other anthropometric variables were evaluated at baseline and at the end of the study. Participants who received liraglutide showed significant improvement in binge eating, accompanied by reduction in body weight, BMI, waist circumference, systolic blood pressure, fasting glucose and total cholesterol. Ghrelin levels were significantly increased which may potentially diminish the weight loss effects of liraglutide beyond the intervention.

Original languageEnglish
Pages (from-to)301-304
Number of pages4
JournalObesity Research and Clinical Practice
Volume9
Issue number3
DOIs
Publication statusPublished - 1 May 2015

Fingerprint

Bulimia
Ghrelin
Blood Pressure
Glucagon-Like Peptide 1
Waist Circumference
Appetite
Therapeutics
Weight Loss
Fasting
Cholesterol
Body Weight
Diet
Glucose
Control Groups
Liraglutide

Keywords

  • Binge eating
  • Ghrelin
  • Glucagon-like peptide-1
  • Liraglutide
  • Obesity

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Improvement in binge eating in non-diabetic obese individuals after 3 months of treatment with liraglutide - A pilot study. / Robert, Sarah Anne; Rohana, Abdul Ghani; Shah, Shamsul Azhar; Chinna, Karuthan; Wan Mohamud, Wan Nazaimoon; Kamaruddin, Nor Azmi.

In: Obesity Research and Clinical Practice, Vol. 9, No. 3, 01.05.2015, p. 301-304.

Research output: Contribution to journalArticle

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