Improved insulin sensitivity, central systolic pressure and inflammatory indicators achieved with minor weight reduction in overweight and obese subjects given education on lifestyle modification

Farah Diana Ariffin, Aaa Ismail, Vina Tan Phei Sean, Zurkurnai Yusoff, Siti Azima Awang, Wan Rimei Wan Abdul Rani, Aida Hanum Ghulam Rasool

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Obesity is a global epidemic disease; lifestyle modification is an approach in the prevention and management of obesity. Objective: We determined the effects of education on modified lifestyle intervention on arterial stiffness, metabolic and inflammatory markers. Methods: Twenty-five generally healthy overweight and obese subjects completed nine months education on modified lifestyle intervention at Hospital Universiti Sains Malaysia, Kota Bharu. Subjects were regularly counselled to increase physical activity and modify their diet during intervention. Arterial stiffness was measured noninvasively using carotid femoral pulse wave velocity (PWV) and pulse wave analysis (PWA). Anthropometric measurements, body fat percentage and visceral fat, central and brachial blood pressures, lipid profile, the inflammatory marker high sensitivity C-reactive protein (hsCRP) and insulin sensitivity were also recorded. Results: After nine months, a significant weight loss of 2.2 kg was observed associated with significant reductions in waist and hip circumference, aortic systolic blood pressure, serum fasting insulin, insulin resistance, and hsCRP levels. Insulin sensitivity was increased, while body fat and visceral fat percentages were marginally reduced (p = 0.058 and p = 0.059). No significant differences were seen in arterial stiffness, fasting plasma glucose and lipid profile. Conclusion: Education on modified lifestyle intervention improved insulin sensitivity and resistance, reduced hsCRP and aortic systolic blood pressure despite the small weight reduction achieved.

Original languageEnglish
Pages (from-to)185-194
Number of pages10
JournalAsian Biomedicine
Volume8
Issue number2
DOIs
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

Insulin Resistance
Life Style
Weight Loss
Education
Vascular Stiffness
Insulin
Blood Pressure
Blood pressure
Fats
C-Reactive Protein
Pulse Wave Analysis
Intra-Abdominal Fat
Stiffness
Adipose Tissue
Fasting
Arterial Pressure
Obesity
Lipids
Malaysia
Waist Circumference

Keywords

  • Arterial stiffness
  • Education on lifestyle modification
  • hsCRP
  • Insulin sensitivity and resistance
  • Obesity

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Improved insulin sensitivity, central systolic pressure and inflammatory indicators achieved with minor weight reduction in overweight and obese subjects given education on lifestyle modification. / Ariffin, Farah Diana; Ismail, Aaa; Sean, Vina Tan Phei; Yusoff, Zurkurnai; Awang, Siti Azima; Rani, Wan Rimei Wan Abdul; Rasool, Aida Hanum Ghulam.

In: Asian Biomedicine, Vol. 8, No. 2, 2014, p. 185-194.

Research output: Contribution to journalArticle

Ariffin, Farah Diana ; Ismail, Aaa ; Sean, Vina Tan Phei ; Yusoff, Zurkurnai ; Awang, Siti Azima ; Rani, Wan Rimei Wan Abdul ; Rasool, Aida Hanum Ghulam. / Improved insulin sensitivity, central systolic pressure and inflammatory indicators achieved with minor weight reduction in overweight and obese subjects given education on lifestyle modification. In: Asian Biomedicine. 2014 ; Vol. 8, No. 2. pp. 185-194.
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