Impact of hormonal replacement therapy on macula and retinal nerve fiber layer in postmenopausal women

Salwa Tharek, Raja Omar, Jemaima Che Hamzah

Research output: Contribution to journalArticle

Abstract

Objective: The objective of this study was to investigate the effect of hormonal replacement therapy (HRT) in postmenopausal women on peripapillary retinal nerve fiber layer (RNFL) and macular thickness and macular volume and to compare them with postmenopausal women who are not on hormonal replacement therapy. Materials and Methods: The study population included postmenopausal women who are taking HRT (n = 50) and postmenopausal women who are not taking HRT (n = 50). Peripapillary retinal nerve fiber layer and macular thickness and macular volume were evaluated using spectral domain-optical coherence tomography. Results: There was no statistically significant difference in all peripapillary RNFL thickness and macular thickness and volume parameters between the two groups, HRT and non-HRT groups, except for superior outer macular thickness and volume were significantly thicker in postmenopausal women who are taking hormonal replacement therapy, P = 0.036 and P = 0.037, respectively. There was a positive correlation between duration on HRT with most of peripapillary RNFL and macular thickness and macular volume, but the correlation was only significant at superotemporal peripapillary RNFL. Conclusion: Our result does not provide strong evidence for a protective effect of postmenopausal HRT usage against ocular diseases. However, the increased macular thickness in superior outer macula and positively correlated peripapillary retinal nerve fiber layer at superotemporal encouraged us to think of promising positive effect of HRT on ocular structure.

Original languageEnglish
Pages (from-to)63-68
Number of pages6
JournalJournal of Pharmaceutical Negative Results
Volume10
Issue number1
DOIs
Publication statusPublished - 1 Jan 2019

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Nerve Fibers
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Keywords

  • Hormonal replacement therapy
  • macula
  • peripapillary nerve fiber layer
  • postmenopausal women
  • spectral domain-optical coherence tomography

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery

Cite this

Impact of hormonal replacement therapy on macula and retinal nerve fiber layer in postmenopausal women. / Tharek, Salwa; Omar, Raja; Che Hamzah, Jemaima.

In: Journal of Pharmaceutical Negative Results, Vol. 10, No. 1, 01.01.2019, p. 63-68.

Research output: Contribution to journalArticle

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