Immunosupressive phenolic constituents from Hypericum montbretii Spach

Ozlem Demirkiran, Osman Mesaik Mohammed Ahmed Hassan, Hayrettin Beynek, Ahmed Abbaskhan, M. Iqbal Choudhary

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The MeOH extract of aerial parts of H. monbretii Spach. have yielded quercetin (1), kaempferol (2), quercitrin (3), hyperin (4), myricitrin (5), rutin (6), I 3 II 8″ biapigenin (7), methyl chlorogenate (8), 5-O-pcoumaroylquinic acid (9), and chlorogenic acid (5-O-caffeoyl quinic acid) (10), mangiferin (11), and shikimic acid (12). Three compounds 1, 2 and 4 were found to have an immunomodulating inhibitory activity on the oxidative burst response of human neutrophils, as well on mouse peritoneal macrophages. Effects of compounds on whole blood phagocytes activity was found to be with IC50 ranging between 8.0-12.2 μg/mL. Only compounds 1, and 2 were found to interfere with T-cell proliferation, and IL-2 release in PHA activated peripheral blood mononuclear cells system. To the best of our knowledge, this is the first report of phytochemical and biological activity study on H. montbretii Spach.

Original languageEnglish
Pages (from-to)210-219
Number of pages10
JournalRecords of Natural Products
Volume7
Issue number3
Publication statusPublished - 28 May 2013
Externally publishedYes

Fingerprint

Shikimic Acid
Quinic Acid
quercitrin
shikimic acid
Hypericum
Chlorogenic Acid
quinic acid
Rutin
Respiratory Burst
phagocytes
Quercetin
Peritoneal Macrophages
Phytochemicals
kaempferol
rutin
chlorogenic acid
Phagocytes
mononuclear leukocytes
interleukin-2
quercetin

Keywords

  • Hypericum monbretii Spach.
  • Il-2 production
  • Immunomodulating inhibitory activity
  • Phenolics
  • Reactive oxygen species
  • T-cell proliferation

ASJC Scopus subject areas

  • Organic Chemistry
  • Drug Discovery
  • Pharmacology
  • Plant Science

Cite this

Demirkiran, O., Mohammed Ahmed Hassan, O. M., Beynek, H., Abbaskhan, A., & Iqbal Choudhary, M. (2013). Immunosupressive phenolic constituents from Hypericum montbretii Spach. Records of Natural Products, 7(3), 210-219.

Immunosupressive phenolic constituents from Hypericum montbretii Spach. / Demirkiran, Ozlem; Mohammed Ahmed Hassan, Osman Mesaik; Beynek, Hayrettin; Abbaskhan, Ahmed; Iqbal Choudhary, M.

In: Records of Natural Products, Vol. 7, No. 3, 28.05.2013, p. 210-219.

Research output: Contribution to journalArticle

Demirkiran, O, Mohammed Ahmed Hassan, OM, Beynek, H, Abbaskhan, A & Iqbal Choudhary, M 2013, 'Immunosupressive phenolic constituents from Hypericum montbretii Spach', Records of Natural Products, vol. 7, no. 3, pp. 210-219.
Demirkiran O, Mohammed Ahmed Hassan OM, Beynek H, Abbaskhan A, Iqbal Choudhary M. Immunosupressive phenolic constituents from Hypericum montbretii Spach. Records of Natural Products. 2013 May 28;7(3):210-219.
Demirkiran, Ozlem ; Mohammed Ahmed Hassan, Osman Mesaik ; Beynek, Hayrettin ; Abbaskhan, Ahmed ; Iqbal Choudhary, M. / Immunosupressive phenolic constituents from Hypericum montbretii Spach. In: Records of Natural Products. 2013 ; Vol. 7, No. 3. pp. 210-219.
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