Immunosuppressive effects of natural α,β-unsaturated carbonyl-based compounds, and their analogs and derivatives, on immune cells: A review

Laiba Arshad, Ibrahim Jantan, Bukhari Syed Nasir Abbas, Md Areeful Haque

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

The immune system is complex and pervasive as it functions to prevent or limit infections in the human body. In a healthy organism, the immune system and the redox balance of immune cells maintain homeostasis within the body. The failure to maintain the balance may lead to impaired immune response and either over activity or abnormally low activity of the immune cells resulting in autoimmune or immune deficiency diseases. Compounds containing α,β-unsaturated carbonyl-based moieties are often reactive. The reactivity of these groups is responsible for their diverse pharmacological activities, and the most important and widely studied include the natural compounds curcumin, chalcone, and zerumbone. Numerous studies have revealed the mainly immunosuppressive and anti-inflammatory activities of the aforesaid compounds. This review highlights the specific immunosuppressive effects of these natural α,β-unsaturated carbonyl-based compounds, and their analogs and derivatives on different types of immune cells of the innate (granulocytes, monocytes, macrophages, and dendritic cells) and adaptive (T cells, B cells, and natural killer cells) immune systems. The inhibitory effects of these compounds have been comprehensively studied on neutrophils, monocytes and macrophages but their effects on T cells, B cells, natural killer cells, and dendritic cells have not been well investigated. It is of paramount importance to continue generating experimental data on the mechanisms of action of α,β-unsaturated carbonyl-based compounds on immune cells to provide useful information for ensuing research to discover new immunomodulating agents.

Original languageEnglish
Article number22
JournalFrontiers in Pharmacology
Volume8
Issue numberJAN
DOIs
Publication statusPublished - 30 Jan 2017

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Immunosuppressive Agents
Immune System
Natural Killer Cells
Dendritic Cells
Monocytes
B-Lymphocytes
Macrophages
Chalcone
T-Lymphocytes
Curcumin
Human Body
Granulocytes
Oxidation-Reduction
Neutrophils
Homeostasis
Anti-Inflammatory Agents
Pharmacology
Infection
Research

Keywords

  • Chalcone
  • Curcumin
  • Immune cells
  • Immunosuppressive effects
  • Zerumbone
  • α
  • β-unsaturated carbonyl-based compounds

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Immunosuppressive effects of natural α,β-unsaturated carbonyl-based compounds, and their analogs and derivatives, on immune cells : A review. / Arshad, Laiba; Jantan, Ibrahim; Syed Nasir Abbas, Bukhari; Haque, Md Areeful.

In: Frontiers in Pharmacology, Vol. 8, No. JAN, 22, 30.01.2017.

Research output: Contribution to journalReview article

Arshad, Laiba ; Jantan, Ibrahim ; Syed Nasir Abbas, Bukhari ; Haque, Md Areeful. / Immunosuppressive effects of natural α,β-unsaturated carbonyl-based compounds, and their analogs and derivatives, on immune cells : A review. In: Frontiers in Pharmacology. 2017 ; Vol. 8, No. JAN.
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