Immunomodulatory studies of methyl 4-hydroxybanzoate isolated from vitex agnus-castus

Azizuddin, Osman Mesaik Mohammed Ahmed Hassan, Muhammad Iqbal Choudhary, Khalid Mohammed Khan, Rasool Bakhsh Tareen

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Vitex agnus-castus Linn. (Verbenaceae) is locally known as "Hub-el-faked" and "Sumbhalu-ke-bij". It is abundantly found in Baluchistan (Pakistan) and extensively used for medicinal purpose. Methyl 4-hydroxybenzoate (1) is a very well known compound, was isolated from the aerial parts of Vitex agnus-castus. Methyl 4-hydroxybenzoate (1) was found to be a moderate immunomodulatory and non-cytotoxic activities. The activity was tested in vitro for chemiluminescence, chemotaxis, T-cell proliferation and cytotoxicity. Methyl 4-hydroxybenzoate (1) exhibited a moderate inhibitory effect on oxidative burst of neutrophils in a dose dependent manner. It was found to have a moderate suppressive effect on the chemotaxic action at lower concentrations on fMLP (10 -8 M) stimulated neutrophils. It also showed a suppressive effect on PHA stimulated T-cell (PMBC).

Original languageEnglish
Pages (from-to)971-975
Number of pages5
JournalJournal of Chemical Society of Pakistan
Volume34
Issue number4
Publication statusPublished - Aug 2012
Externally publishedYes

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T-cells
Chemiluminescence
Cell proliferation
Cytotoxicity
Antennas
methylparaben

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Azizuddin, Mohammed Ahmed Hassan, O. M., Choudhary, M. I., Khan, K. M., & Tareen, R. B. (2012). Immunomodulatory studies of methyl 4-hydroxybanzoate isolated from vitex agnus-castus. Journal of Chemical Society of Pakistan, 34(4), 971-975.

Immunomodulatory studies of methyl 4-hydroxybanzoate isolated from vitex agnus-castus. / Azizuddin; Mohammed Ahmed Hassan, Osman Mesaik; Choudhary, Muhammad Iqbal; Khan, Khalid Mohammed; Tareen, Rasool Bakhsh.

In: Journal of Chemical Society of Pakistan, Vol. 34, No. 4, 08.2012, p. 971-975.

Research output: Contribution to journalArticle

Azizuddin, Mohammed Ahmed Hassan, OM, Choudhary, MI, Khan, KM & Tareen, RB 2012, 'Immunomodulatory studies of methyl 4-hydroxybanzoate isolated from vitex agnus-castus', Journal of Chemical Society of Pakistan, vol. 34, no. 4, pp. 971-975.
Azizuddin, Mohammed Ahmed Hassan OM, Choudhary MI, Khan KM, Tareen RB. Immunomodulatory studies of methyl 4-hydroxybanzoate isolated from vitex agnus-castus. Journal of Chemical Society of Pakistan. 2012 Aug;34(4):971-975.
Azizuddin ; Mohammed Ahmed Hassan, Osman Mesaik ; Choudhary, Muhammad Iqbal ; Khan, Khalid Mohammed ; Tareen, Rasool Bakhsh. / Immunomodulatory studies of methyl 4-hydroxybanzoate isolated from vitex agnus-castus. In: Journal of Chemical Society of Pakistan. 2012 ; Vol. 34, No. 4. pp. 971-975.
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