Immunomodulatory properties of various natural compounds and essential oils through modulation of human cellular immune response

Ilkay Erdogan Orhan, Osman Mesaik Mohammed Ahmed Hassan, Almas Jabeen, Yuksel Kan

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Randomly selected essential oils and some terpene and phenolic derivatives were evaluated for their ability to modulate human cellular immune responses using various inflammatory parameters including reactive oxygen species (ROS) generation from whole blood phagocytes and isolated polymorphonuclear neutrophils (PMNs), proliferation of T-cells, IL-2. and TNF-α cytokine production. The essential oils from Foeniculum vulgare, Saturea cuneifolia, and Origanum munitiflorum inhibited ROS produced from whole blood phagocytes, while thymol, carvacrol, rosmarinic acid, caffeic acid, quercetin, and kaempferol glycoside potently inhibited the ROS production from whole blood as well as from isolated PMNs, among which caffeic acid, quercetin, and kaempferol glycoside exhibited a better inhibitory effect than that of ibuprofen. The compounds rosmarinic acid, caffeic acid, quercetin, kaempferol glycoside, genistein, and apigenin (IC50 7.0±0.5, 50 2.9±0.3μg/mL) and apigenin (IC50

Original languageEnglish
Pages (from-to)117-122
Number of pages6
JournalIndustrial Crops and Products
Volume81
DOIs
Publication statusPublished - 1 Mar 2016

Fingerprint

kaempferol
caffeic acid
cell-mediated immunity
quercetin
glycosides
reactive oxygen species
rosmarinic acid
essential oils
apigenin
phagocytes
inhibitory concentration 50
neutrophils
blood
ibuprofen
Origanum
Foeniculum vulgare
carvacrol
thymol
genistein
interleukin-2

Keywords

  • Cytokine
  • Essential oil
  • Immunomodulatory activity
  • Natural compound
  • ROS
  • T-cell proliferation
  • TNF-α

ASJC Scopus subject areas

  • Agronomy and Crop Science

Cite this

Immunomodulatory properties of various natural compounds and essential oils through modulation of human cellular immune response. / Orhan, Ilkay Erdogan; Mohammed Ahmed Hassan, Osman Mesaik; Jabeen, Almas; Kan, Yuksel.

In: Industrial Crops and Products, Vol. 81, 01.03.2016, p. 117-122.

Research output: Contribution to journalArticle

Orhan, Ilkay Erdogan ; Mohammed Ahmed Hassan, Osman Mesaik ; Jabeen, Almas ; Kan, Yuksel. / Immunomodulatory properties of various natural compounds and essential oils through modulation of human cellular immune response. In: Industrial Crops and Products. 2016 ; Vol. 81. pp. 117-122.
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