Immunomodulatory properties of synthetic imidazolone derivatives

Osman Mesaik Mohammed Ahmed Hassan, K. M. Khan, S. Rahat, Zia-Ullah, M. I. Choudhary, S. Murad, N. R. Abdullah, Z. Ismail, Atta-Ur-Rahman, A. Ahmad, R. A. Siddiqui

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Thirteen imidazolone derivatives were synthesized and characterized by 1H NMR, EI, IR and UV spectroscopic and CHN analysis. Among the compounds tested, two compounds, 3-hydroxy-2-phenyl-5-[E-phenylmethylidene]-3,5- dihydro-4H-imidazol-4-one (12) and 4-[E-(5-methyl-2-furyl) methylidene]-1,2- diphenyl-1H-imidazol-5-one (13) shown to have suppressing activities on the oxidative burst of neutrophils. These two compounds were then further investigated for their effects on different cellular immune responses including neutrophils, phagocytosis and chemotaxis activities of T-cell proliferation, and cytokine production from mononuclear cells. The results demonstrate that compounds 12 and 13 inhibit reactive oxygen species (ROS) generation and phytohemagglutinin (PHA)-induced T-cell proliferation in a dose dependent manner.

Original languageEnglish
Pages (from-to)490-496
Number of pages7
JournalLetters in Drug Design and Discovery
Volume2
Issue number6
DOIs
Publication statusPublished - Sep 2005
Externally publishedYes

Fingerprint

Neutrophils
Cell Proliferation
T-Lymphocytes
Respiratory Burst
Phytohemagglutinins
Chemotaxis
Phagocytosis
Cellular Immunity
Reactive Oxygen Species
Cytokines
imidazolone
diphenyl
Proton Magnetic Resonance Spectroscopy

Keywords

  • Cell proliferation
  • Chemotaxis
  • Imidazolone derivative
  • Immunomodulation
  • Oxidative burst

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Molecular Medicine

Cite this

Mohammed Ahmed Hassan, O. M., Khan, K. M., Rahat, S., Zia-Ullah, Choudhary, M. I., Murad, S., ... Siddiqui, R. A. (2005). Immunomodulatory properties of synthetic imidazolone derivatives. Letters in Drug Design and Discovery, 2(6), 490-496. https://doi.org/10.2174/1570180054771554

Immunomodulatory properties of synthetic imidazolone derivatives. / Mohammed Ahmed Hassan, Osman Mesaik; Khan, K. M.; Rahat, S.; Zia-Ullah; Choudhary, M. I.; Murad, S.; Abdullah, N. R.; Ismail, Z.; Atta-Ur-Rahman; Ahmad, A.; Siddiqui, R. A.

In: Letters in Drug Design and Discovery, Vol. 2, No. 6, 09.2005, p. 490-496.

Research output: Contribution to journalArticle

Mohammed Ahmed Hassan, OM, Khan, KM, Rahat, S, Zia-Ullah, Choudhary, MI, Murad, S, Abdullah, NR, Ismail, Z, Atta-Ur-Rahman, Ahmad, A & Siddiqui, RA 2005, 'Immunomodulatory properties of synthetic imidazolone derivatives', Letters in Drug Design and Discovery, vol. 2, no. 6, pp. 490-496. https://doi.org/10.2174/1570180054771554
Mohammed Ahmed Hassan, Osman Mesaik ; Khan, K. M. ; Rahat, S. ; Zia-Ullah ; Choudhary, M. I. ; Murad, S. ; Abdullah, N. R. ; Ismail, Z. ; Atta-Ur-Rahman ; Ahmad, A. ; Siddiqui, R. A. / Immunomodulatory properties of synthetic imidazolone derivatives. In: Letters in Drug Design and Discovery. 2005 ; Vol. 2, No. 6. pp. 490-496.
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