Immunomodulatory effects of diarylpentanoid analogues of curcumin

Bukhari Syed Nasir Abbas, Ibrahim Jantan, Kumolosasi Msi Endang, Malina Jasamai

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Diarylpentanoid analogues of curcumin are known for their various pharmacological activities which include the inhibition of inflammatory mediators and are good candidates as immunomodulators that could be useful in the treatment of inflammation. In the work described here, seventeen diarylpentanoid curcumin analogues were assessed for their inhibitory effects on the reactive oxygen species (ROS) production, chemotaxis and phagocytosis of human neutrophils. ROS production was evaluated using luminol and lucigenin-based chemiluminesence assay, while inhibition of isolated polymorphonuclear neutrophils chemotaxis and phagocytosis abilities were investigated using the Boyden chamber technique and the Phagotest kit, respectively. Two of the analogues, compounds 1e and 2e, which contain the 2-methyl-4(N-ethyl-N-ethylacetonitrile)aniline functional group, were active in all the assays performed. Moreover, analogues containing heteroatoms (1a, 1e, 2c, 2d, 2e, 3a and 3c) were active in suppressing the neutrophil phagocytic activity. The information obtained gave new insight into curcumin analogues with the potential to be developed as new immunomodulators.

Original languageEnglish
Pages (from-to)3405-3411
Number of pages7
JournalMedicinal Chemistry Research
Volume24
Issue number9
DOIs
Publication statusPublished - 27 Sep 2015

Fingerprint

Curcumin
Neutrophils
Immunologic Factors
Chemotaxis
Phagocytosis
Assays
Reactive Oxygen Species
Luminol
Aptitude
Functional groups
Pharmacology
Inflammation
Inhibition (Psychology)
Therapeutics

Keywords

  • Chemotaxis
  • Curcumin
  • Diarylpentanoid
  • Phagocytosis
  • Reactive oxygen species
  • Structure-activity relationship

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

Cite this

Immunomodulatory effects of diarylpentanoid analogues of curcumin. / Syed Nasir Abbas, Bukhari; Jantan, Ibrahim; Endang, Kumolosasi Msi; Jasamai, Malina.

In: Medicinal Chemistry Research, Vol. 24, No. 9, 27.09.2015, p. 3405-3411.

Research output: Contribution to journalArticle

Syed Nasir Abbas, Bukhari ; Jantan, Ibrahim ; Endang, Kumolosasi Msi ; Jasamai, Malina. / Immunomodulatory effects of diarylpentanoid analogues of curcumin. In: Medicinal Chemistry Research. 2015 ; Vol. 24, No. 9. pp. 3405-3411.
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