Immunomodulatory effectiveness of fish oil and omega-3 fatty acids in human non-melanoma skin carcinoma cells

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5 Citations (Scopus)

Abstract

Fish oil is composed of various fatty acids among which omega-3 fatty acids are considered as most beneficial. The effects of fish oil on the activity of a topical anticancer drug, imiquimod, and the immunomodulatory activity of omega-3 fatty acids was investigated in human basal and squamous cell carcinoma cell lines. Imiquimod-fish oil mixture exhibited higher carcinoma cell growth inhibition and immunomodulatory activity than imiquimod alone, especially against squamous cell carcinoma cells. Omega-3 fatty acids exhibited growth inhibition of both basal cell and squamous cell carcinoma cell lines and modulated the immune response. Omega-3 fatty acids of fish oil serve as inducers of interleukin-10, an anti-inflammatory cytokine, and as suppressors of interleukin-6 and tumor necrosis factor-alpha, which not only depress tumor growth but also adequately control the inflammatory side effects of imiquimod. Thus, imiquimod administration with fish oil could be beneficial for inhibition of non-melanoma skin carcinoma cells but further in vivo studies are needed to understand their role in skin cancer.

Original languageEnglish
Pages (from-to)217-224
Number of pages8
JournalJournal of Oleo Science
Volume65
Issue number3
DOIs
Publication statusPublished - 1 Mar 2016

Fingerprint

imiquimod
Fish Oils
Omega-3 Fatty Acids
Fatty acids
Fish
Skin
Cells
Cell growth
Interleukin-10
Tumors
Interleukin-6
Anti-Inflammatory Agents
Fatty Acids
Tumor Necrosis Factor-alpha
Oils
Cytokines
Pharmaceutical Preparations

Keywords

  • Basal cell carcinoma
  • Docosahexaenoic acid
  • Eicosapentaenoic acid
  • Fish oil
  • Immunomodulatory
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Chemistry(all)

Cite this

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title = "Immunomodulatory effectiveness of fish oil and omega-3 fatty acids in human non-melanoma skin carcinoma cells",
abstract = "Fish oil is composed of various fatty acids among which omega-3 fatty acids are considered as most beneficial. The effects of fish oil on the activity of a topical anticancer drug, imiquimod, and the immunomodulatory activity of omega-3 fatty acids was investigated in human basal and squamous cell carcinoma cell lines. Imiquimod-fish oil mixture exhibited higher carcinoma cell growth inhibition and immunomodulatory activity than imiquimod alone, especially against squamous cell carcinoma cells. Omega-3 fatty acids exhibited growth inhibition of both basal cell and squamous cell carcinoma cell lines and modulated the immune response. Omega-3 fatty acids of fish oil serve as inducers of interleukin-10, an anti-inflammatory cytokine, and as suppressors of interleukin-6 and tumor necrosis factor-alpha, which not only depress tumor growth but also adequately control the inflammatory side effects of imiquimod. Thus, imiquimod administration with fish oil could be beneficial for inhibition of non-melanoma skin carcinoma cells but further in vivo studies are needed to understand their role in skin cancer.",
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author = "Khurram Rehman and {Mohd Amin}, {Mohd Cairul Iqbal} and Ng, {Pei Yuen} and Zulfakar, {Mohd Hanif}",
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AU - Rehman, Khurram

AU - Mohd Amin, Mohd Cairul Iqbal

AU - Ng, Pei Yuen

AU - Zulfakar, Mohd Hanif

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Fish oil is composed of various fatty acids among which omega-3 fatty acids are considered as most beneficial. The effects of fish oil on the activity of a topical anticancer drug, imiquimod, and the immunomodulatory activity of omega-3 fatty acids was investigated in human basal and squamous cell carcinoma cell lines. Imiquimod-fish oil mixture exhibited higher carcinoma cell growth inhibition and immunomodulatory activity than imiquimod alone, especially against squamous cell carcinoma cells. Omega-3 fatty acids exhibited growth inhibition of both basal cell and squamous cell carcinoma cell lines and modulated the immune response. Omega-3 fatty acids of fish oil serve as inducers of interleukin-10, an anti-inflammatory cytokine, and as suppressors of interleukin-6 and tumor necrosis factor-alpha, which not only depress tumor growth but also adequately control the inflammatory side effects of imiquimod. Thus, imiquimod administration with fish oil could be beneficial for inhibition of non-melanoma skin carcinoma cells but further in vivo studies are needed to understand their role in skin cancer.

AB - Fish oil is composed of various fatty acids among which omega-3 fatty acids are considered as most beneficial. The effects of fish oil on the activity of a topical anticancer drug, imiquimod, and the immunomodulatory activity of omega-3 fatty acids was investigated in human basal and squamous cell carcinoma cell lines. Imiquimod-fish oil mixture exhibited higher carcinoma cell growth inhibition and immunomodulatory activity than imiquimod alone, especially against squamous cell carcinoma cells. Omega-3 fatty acids exhibited growth inhibition of both basal cell and squamous cell carcinoma cell lines and modulated the immune response. Omega-3 fatty acids of fish oil serve as inducers of interleukin-10, an anti-inflammatory cytokine, and as suppressors of interleukin-6 and tumor necrosis factor-alpha, which not only depress tumor growth but also adequately control the inflammatory side effects of imiquimod. Thus, imiquimod administration with fish oil could be beneficial for inhibition of non-melanoma skin carcinoma cells but further in vivo studies are needed to understand their role in skin cancer.

KW - Basal cell carcinoma

KW - Docosahexaenoic acid

KW - Eicosapentaenoic acid

KW - Fish oil

KW - Immunomodulatory

KW - Squamous cell carcinoma

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