IGF-1 and IGFBP-3 screening for disorders of growth hormone secretion

Rahmah Rasat, John L. Livesey, Eric A. Espiner, George D. Abbott, Richard A. Donald

Research output: Contribution to journalArticle

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Abstract

Aim. To assess the value of plasma assays of insulin like growth factor (IGF-1) and insulin like growth factor binding protein 3 (IGFBP-3) in the diagnosis of growth hormone disorders in children and adults. Methods. Plasma IGF-1 and IGFBP-3 were measured in 47 children referred for the assessment of short stature, 26 adult subjects with hypopituitarism and in 10 adult subjects with acromegaly. Findings were compared with results obtained in 148 normal children and 124 normal adult subjects who comprised the reference range. Results. Levels of both growth factors and especially IGF-1 are highly age dependent in normal children and adults. Six of 47 short children had growth hormone deficiency and in these cases both IGF-1 and IGFBP-3 were close to the lower limit or below the normal reference range. In young children (<10 yr) IGFBP-3 was more informative than IGF-1, distinguishing normal short children from those with growth hormone deficiency. IGF-1 levels were raised in all 10 acromegalic adults, eight of whom had normal levels of IGFBP-3. Similarly growth hormone deficient adults were better identified (23 of 26 patients) by IGF-1 whereas IGFBP-3 was subnormal in only eight cases. Conclusions. Provided results are reviewed in relation to an age related normal reference range, both IGF-1 and IGFBP-3 are simple and convenient screening tests for assessing growth hormone deficiency in children. In adults plasma IGF-1 is the diagnostic test for a disorder of growth hormone excess. Low IGF-1 in an adult with a history of pituitary disease strongly suggests the presence of growth hormone deficiency.

Original languageEnglish
Pages (from-to)156-159
Number of pages4
JournalNew Zealand Medical Journal
Volume109
Issue number1021
Publication statusPublished - 10 May 1996
Externally publishedYes

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Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor I
Growth Hormone
Reference Values
Pituitary Diseases
Growth Disorders
Hypopituitarism
Acromegaly
Somatomedins
Routine Diagnostic Tests
Intercellular Signaling Peptides and Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Rasat, R., Livesey, J. L., Espiner, E. A., Abbott, G. D., & Donald, R. A. (1996). IGF-1 and IGFBP-3 screening for disorders of growth hormone secretion. New Zealand Medical Journal, 109(1021), 156-159.

IGF-1 and IGFBP-3 screening for disorders of growth hormone secretion. / Rasat, Rahmah; Livesey, John L.; Espiner, Eric A.; Abbott, George D.; Donald, Richard A.

In: New Zealand Medical Journal, Vol. 109, No. 1021, 10.05.1996, p. 156-159.

Research output: Contribution to journalArticle

Rasat, R, Livesey, JL, Espiner, EA, Abbott, GD & Donald, RA 1996, 'IGF-1 and IGFBP-3 screening for disorders of growth hormone secretion', New Zealand Medical Journal, vol. 109, no. 1021, pp. 156-159.
Rasat R, Livesey JL, Espiner EA, Abbott GD, Donald RA. IGF-1 and IGFBP-3 screening for disorders of growth hormone secretion. New Zealand Medical Journal. 1996 May 10;109(1021):156-159.
Rasat, Rahmah ; Livesey, John L. ; Espiner, Eric A. ; Abbott, George D. ; Donald, Richard A. / IGF-1 and IGFBP-3 screening for disorders of growth hormone secretion. In: New Zealand Medical Journal. 1996 ; Vol. 109, No. 1021. pp. 156-159.
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