IgE-mediated hypersensitivity to chlorhexidine among first-year dental students

Sobrina Mohamed Khazin, Dalia Abdullah, Kia Cheen Amy Liew, Nor Adilah Harun, Noormalin Abdullah, Bun San Chong

Research output: Contribution to journalArticle

Abstract

Purpose: To investigate immunoglobulin E (IgE)-mediated hypersensitivity to chlorhexidine (CHX), and association between CHX exposure and serum specific IgE (SIgE) levels, among first-year dental students. Methods: Participants completed a questionnaire on medical health, history of allergies/hypersensitivities and CHX exposure. A sample of venous blood (3 mL) was drawn and subjected to SIgE test to CHX; sensitisation defined as SIgE level of ≥0.10 kUA/L. Results: Fifty-eight (98.3%) participants, consisting of 69% (n = 40) female with a mean age of 21, were recruited; three quarters (84%) reported no known health issue, and over half had no history of allergies (57%); less than 20% reported having had exposure to CHX-containing products with the majority from toothpaste (9%) and mouthwash (12%). The CHX SIgE test showed that 8.6% (n = 5) were sensitised. No association between CHX exposure history and the level of SIgE antibody was noted. Conclusions: Although most participants reported no known exposure to CHX, 8.6% showed CHX sensitisation suggesting unknown exposure and the potential risk of developing hypersensitivity and adverse reactions in the future.

Original languageEnglish
JournalAllergo Journal International
DOIs
Publication statusAccepted/In press - 1 Jan 2019

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Dental Students
Chlorhexidine
Hypersensitivity
Immunoglobulin E
Mouthwashes
Toothpastes
Health
History
Antibodies

Keywords

  • IgE-mediated
  • ImmunoCAP test
  • Occupational health
  • Sensitisation
  • Serum specific

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

IgE-mediated hypersensitivity to chlorhexidine among first-year dental students. / Mohamed Khazin, Sobrina; Abdullah, Dalia; Liew, Kia Cheen Amy; Harun, Nor Adilah; Abdullah, Noormalin; Chong, Bun San.

In: Allergo Journal International, 01.01.2019.

Research output: Contribution to journalArticle

Mohamed Khazin, Sobrina ; Abdullah, Dalia ; Liew, Kia Cheen Amy ; Harun, Nor Adilah ; Abdullah, Noormalin ; Chong, Bun San. / IgE-mediated hypersensitivity to chlorhexidine among first-year dental students. In: Allergo Journal International. 2019.
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