Identifying hub proteins and their essentiality from protein-protein interaction network

Sakhinah Abu Bakar, Javid Taheri, Albert Y. Zomaya

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The study on protein-protein interactions is rapidly increasing; one of the most important findings of such study is the observation of hub proteins that play vital roles in all organisms. Identifying hub proteins may provide more information on essential proteins and lead to more efficient methods for their prediction. Here, we proposed a new network topological-based method for prediction of hub proteins in Saccharomyces cerevisiae (baker's yeast). The method, HP3NN (Hub Protein Prediction using Probabilistic Neural Network), has successfully predicts the hub proteins with accuracy of 95% (sensitivity of 1.0 and specificity of 0.89).

Original languageEnglish
Title of host publicationProceedings - 2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011
Pages266-269
Number of pages4
DOIs
Publication statusPublished - 2011
Event2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011 - Taichung
Duration: 24 Oct 201126 Oct 2011

Other

Other2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011
CityTaichung
Period24/10/1126/10/11

Fingerprint

Proteins
Yeast
Neural networks

Keywords

  • hub proteins
  • machine learning algorithms
  • neural networks
  • protein-protein interaction network

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

Cite this

Abu Bakar, S., Taheri, J., & Zomaya, A. Y. (2011). Identifying hub proteins and their essentiality from protein-protein interaction network. In Proceedings - 2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011 (pp. 266-269). [6092532] https://doi.org/10.1109/BIBE.2011.67

Identifying hub proteins and their essentiality from protein-protein interaction network. / Abu Bakar, Sakhinah; Taheri, Javid; Zomaya, Albert Y.

Proceedings - 2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011. 2011. p. 266-269 6092532.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abu Bakar, S, Taheri, J & Zomaya, AY 2011, Identifying hub proteins and their essentiality from protein-protein interaction network. in Proceedings - 2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011., 6092532, pp. 266-269, 2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011, Taichung, 24/10/11. https://doi.org/10.1109/BIBE.2011.67
Abu Bakar S, Taheri J, Zomaya AY. Identifying hub proteins and their essentiality from protein-protein interaction network. In Proceedings - 2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011. 2011. p. 266-269. 6092532 https://doi.org/10.1109/BIBE.2011.67
Abu Bakar, Sakhinah ; Taheri, Javid ; Zomaya, Albert Y. / Identifying hub proteins and their essentiality from protein-protein interaction network. Proceedings - 2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011. 2011. pp. 266-269
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