Identification of Schizosaccharomyces pombe in the guts of healthy individuals and patients with colorectal cancer

Preliminary evidence from a gut microbiome secretome study

Siok Fong Chin, Putri Intan Hafizah Megat Mohd Azlan, Luqman Mazlan, Hui Min Neoh

Research output: Contribution to journalArticle

Abstract

Over the years, genetic profiling of the gut microbiome of patients with colorectal cancer (CRC) using genome sequencing has suggested over-representation of several bacterial taxa. However, little is known about the protein or metabolite secretions from the microbiota that could lead to CRC pathology. Proteomic studies on the role of microbial secretome in CRC are relatively rare. Here, we report the identification of proteins from Schizosaccharomyces pombe found in the stool samples of both healthy individuals and patients with CRC. We found that distinctive sets of S. pombe proteins were present exclusively and in high intensities in each group. Our finding may trigger a new interest in the role of gut mycobiota in carcinogenesis.

Original languageEnglish
Article number29
JournalGut Pathogens
Volume10
Issue number1
DOIs
Publication statusPublished - 10 Jul 2018

Fingerprint

Schizosaccharomyces
Colorectal Neoplasms
Schizosaccharomyces pombe Proteins
Microbiota
Proteomics
Carcinogenesis
Genome
Pathology
Gastrointestinal Microbiome
Proteins

Keywords

  • Colorectal cancer
  • Human gut
  • Microbiome
  • Schizosaccharomyces pombe
  • Secretome

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Gastroenterology
  • Virology
  • Infectious Diseases

Cite this

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abstract = "Over the years, genetic profiling of the gut microbiome of patients with colorectal cancer (CRC) using genome sequencing has suggested over-representation of several bacterial taxa. However, little is known about the protein or metabolite secretions from the microbiota that could lead to CRC pathology. Proteomic studies on the role of microbial secretome in CRC are relatively rare. Here, we report the identification of proteins from Schizosaccharomyces pombe found in the stool samples of both healthy individuals and patients with CRC. We found that distinctive sets of S. pombe proteins were present exclusively and in high intensities in each group. Our finding may trigger a new interest in the role of gut mycobiota in carcinogenesis.",
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AU - Mazlan, Luqman

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AB - Over the years, genetic profiling of the gut microbiome of patients with colorectal cancer (CRC) using genome sequencing has suggested over-representation of several bacterial taxa. However, little is known about the protein or metabolite secretions from the microbiota that could lead to CRC pathology. Proteomic studies on the role of microbial secretome in CRC are relatively rare. Here, we report the identification of proteins from Schizosaccharomyces pombe found in the stool samples of both healthy individuals and patients with CRC. We found that distinctive sets of S. pombe proteins were present exclusively and in high intensities in each group. Our finding may trigger a new interest in the role of gut mycobiota in carcinogenesis.

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