Identification and characterization of burkholderia pseudomallei K96243 serine and metallopeptidases

Noraslinda M. Bunnori, Rahmah Mohamed

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    1 Citation (Scopus)

    Abstract

    Burkholderia pseudomallei K96243, the causative agent of melioidosis, is reported to produce various extracellular products, including proteases. The role of these proteases in the melioidosis, however, remains obscure. Previous findings have hinted at the inherent pathogenicity of the protease during B. pseudomallei K96243 infection. We chose to study the two major families peptidases, i.e. serine peptidases and metallopeptidases present in B. pseudomallei K96243. The data mining revealed eighty ORFs (open reading frame) that potentially code for these peptidases and have prominent homology with B. pseudomallei K96243 based on prediction of function by bioinformatics approach. The annotations and classification lead forty eight and thirty two putative peptidases belong to serine peptidase and metallopeptidase, respectively. The distribution of 98% from the identified putative peptidase belongs to endopeptidases (EC 3.4.21. and EC 3.4.24.) and exopeptidases (EC 3.4.11., EC 3.4.13., EC 3.4.14., EC 3.4.16. and EC 3.4.17) and another 2% belong to EC 3.5.

    Original languageEnglish
    Title of host publicationProcedia Computer Science
    PublisherElsevier
    Pages36-42
    Number of pages7
    Volume11
    DOIs
    Publication statusPublished - 2012
    Event3rd International Conference on Computational Systems-Biology and Bioinformatics, CSBio 2012 - Bangkok, Thailand
    Duration: 3 Oct 20125 Oct 2012

    Other

    Other3rd International Conference on Computational Systems-Biology and Bioinformatics, CSBio 2012
    CountryThailand
    CityBangkok
    Period3/10/125/10/12

    Fingerprint

    Peptide Hydrolases
    Metalloproteases
    Bioinformatics
    Data mining
    Exopeptidases
    Endopeptidases

    Keywords

    • Burkholderia pseudomallei
    • Metallopeptidases
    • Serine

    ASJC Scopus subject areas

    • Computer Science(all)

    Cite this

    Bunnori, N. M., & Mohamed, R. (2012). Identification and characterization of burkholderia pseudomallei K96243 serine and metallopeptidases. In Procedia Computer Science (Vol. 11, pp. 36-42). Elsevier. https://doi.org/10.1016/j.procs.2012.09.005

    Identification and characterization of burkholderia pseudomallei K96243 serine and metallopeptidases. / Bunnori, Noraslinda M.; Mohamed, Rahmah.

    Procedia Computer Science. Vol. 11 Elsevier, 2012. p. 36-42.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Bunnori, NM & Mohamed, R 2012, Identification and characterization of burkholderia pseudomallei K96243 serine and metallopeptidases. in Procedia Computer Science. vol. 11, Elsevier, pp. 36-42, 3rd International Conference on Computational Systems-Biology and Bioinformatics, CSBio 2012, Bangkok, Thailand, 3/10/12. https://doi.org/10.1016/j.procs.2012.09.005
    Bunnori, Noraslinda M. ; Mohamed, Rahmah. / Identification and characterization of burkholderia pseudomallei K96243 serine and metallopeptidases. Procedia Computer Science. Vol. 11 Elsevier, 2012. pp. 36-42
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