Hypoxia Increases Thyroid Cancer Stem Cell-Enriched Side Population

K. Mahkamova, Nani Harlina Md. Latar, S. Aspinall, A. Meeson

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Introduction: Hypoxic stress is a feature of rapidly growing thyroid tumours. Cancer progression is thought to be driven by a small population of tumour cells possessing stem cell properties. Hypoxia-inducible factors (HIFs) are important mediators of hypoxia. Both HIF-1alpha and HIF-2alpha have been reported to be expressed in thyroid cancers. There is growing evidence that the HIF pathway plays a significant role in the maintenance of thyroid cancer stem cells (CSC). Methodology: We have isolated thyroid CSC from a papillary thyroid cancer-derived cell line (BCPAP) and an anaplastic thyroid cancer-derived cell line (SW1736) as side population (SP) cells (a putative stem cell population) and treated them with cobalt chloride (II) to induce hypoxia. Results and discussion: We observed an increase in the SP of cells within the thyroid cancer cell lines following induction of hypoxia.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalWorld Journal of Surgery
DOIs
Publication statusAccepted/In press - 22 Nov 2017
Externally publishedYes

Fingerprint

Neoplastic Stem Cells
Thyroid Neoplasms
Population
Side-Population Cells
Cell Line
Stem Cells
Neoplasms
Hypoxia
Thyroid Gland
Maintenance

ASJC Scopus subject areas

  • Surgery

Cite this

Hypoxia Increases Thyroid Cancer Stem Cell-Enriched Side Population. / Mahkamova, K.; Md. Latar, Nani Harlina; Aspinall, S.; Meeson, A.

In: World Journal of Surgery, 22.11.2017, p. 1-8.

Research output: Contribution to journalArticle

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