Hypoglycemic, insulinotrophic and cytotoxic activity of three species of Ganoderma

Mohd Saufi Bastami, Siti Pauliena Mohd Bohari, Wong Mee Har, Mohd Noor Wahab, Ariffi Suraya Rahmani, Nor Fadilah Rajab, Muhajir Hamid

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The crude extracts of Ganoderma lucidum, Ganoderma tropicum and Ganoderma tsugae were studied for insulinotrophic and hypoglycemic activities using rat pancreatic β-cell lines, BRIN-BD11 cells and normal Wistar rats. In an oral glucose tolerance test (OGTT), oral administration of 1 g/kg body weight of the crude extract resulted in a significant reduction in blood glucose in the normal rats. In acute 30 min insulin secretion tests, 1 mg/ml crude extract of all tested Ganoderma evoked a 1 - 4 fold stimulation of insulin secretion from the pancreatic β-cell lines. Of these, G. lucidum showed the highest insulinotrophic activity. In addition, cytotoxicity assay of extracts from G. lucidum, G. tropicum and G. tsugae towards rat pancreatic β-cell lines showed hall maximal inhibition (IC50) at 200, 100 and 150μg/ml, respectively. These results demonstrated the presence of insulin-releasing and hypoglycemic activity in the crude extracts of G. lucidum, G. tropicum and G. tsugae.

Original languageEnglish
Pages (from-to)41-46
Number of pages6
JournalMalaysian Journal of Science
Volume26
Issue number2
Publication statusPublished - Dec 2007

Fingerprint

Ganoderma
Reishi
Hypoglycemic Agents
Complex Mixtures
Insulin
Cell Line
Glucose Tolerance Test
Inhibitory Concentration 50
Oral Administration
Blood Glucose
Wistar Rats
Body Weight

Keywords

  • Ganoderma
  • Hypoglycemic
  • Insulinotrophic
  • Rat pancreatic β-cell lines

ASJC Scopus subject areas

  • General

Cite this

Bastami, M. S., Bohari, S. P. M., Har, W. M., Wahab, M. N., Rahmani, A. S., Rajab, N. F., & Hamid, M. (2007). Hypoglycemic, insulinotrophic and cytotoxic activity of three species of Ganoderma. Malaysian Journal of Science, 26(2), 41-46.

Hypoglycemic, insulinotrophic and cytotoxic activity of three species of Ganoderma. / Bastami, Mohd Saufi; Bohari, Siti Pauliena Mohd; Har, Wong Mee; Wahab, Mohd Noor; Rahmani, Ariffi Suraya; Rajab, Nor Fadilah; Hamid, Muhajir.

In: Malaysian Journal of Science, Vol. 26, No. 2, 12.2007, p. 41-46.

Research output: Contribution to journalArticle

Bastami, MS, Bohari, SPM, Har, WM, Wahab, MN, Rahmani, AS, Rajab, NF & Hamid, M 2007, 'Hypoglycemic, insulinotrophic and cytotoxic activity of three species of Ganoderma', Malaysian Journal of Science, vol. 26, no. 2, pp. 41-46.
Bastami MS, Bohari SPM, Har WM, Wahab MN, Rahmani AS, Rajab NF et al. Hypoglycemic, insulinotrophic and cytotoxic activity of three species of Ganoderma. Malaysian Journal of Science. 2007 Dec;26(2):41-46.
Bastami, Mohd Saufi ; Bohari, Siti Pauliena Mohd ; Har, Wong Mee ; Wahab, Mohd Noor ; Rahmani, Ariffi Suraya ; Rajab, Nor Fadilah ; Hamid, Muhajir. / Hypoglycemic, insulinotrophic and cytotoxic activity of three species of Ganoderma. In: Malaysian Journal of Science. 2007 ; Vol. 26, No. 2. pp. 41-46.
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