Hypocholesterolemic activity of Monascus fermented product in the absence of monacolins with partial purification for functional food applications

Zahra Ajdari, Ma`Aruf Abd. Ghani, Mohd. Khan Ayob, Saadi Bayat, Mazlin Mokhtar, Sahar Abbasiliasi, Anahita Khoramnia, Heshu Sulaiman Rahman, Parvaneh Mehrbod, Daniel Ajdari, Arbakariya B. Ariff

Research output: Contribution to journalArticle

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Abstract

Hypercholesterolemia is one of the most common chronic diseases in human. Along with chemical therapy traditional medication is used as hypocholesterolemic remedy, however, with unfavorable side effects. Recently, Monascus fermented product (MFP) has become a popular hypocholesterolemic natural supplement. In the present study, the hypocholesterolemic activity of Monascus purpureus FTC5391 fermented product ethanolic extract (MFPe) was investigated in hypercholesterolemic rats. Results showed that MFPe not only reduced the serum total cholesterol (TC), LDL-C, TG concentration, and TC/HDL-C ratio but also increased the HDL-C. Further, solid phase extraction (SPE) was carried out to obtain the hypocholesterolemic bioactive fraction. The high polar fraction of SPE increased the HDL-C (42%) and decreased the TC (53.3%), LDL-C (47%), and TG (50.7%) levels as well as TC/HDL-C ratio (69.1%) in serum. The GC-MS results of the active fraction revealed two main compounds, isosorbide and erythritol, which act as coronary vasodilator compounds.

Original languageEnglish
Article number252647
JournalThe Scientific World Journal
Volume2014
DOIs
Publication statusPublished - 2014

Fingerprint

Monascus
Functional Food
Solid Phase Extraction
LDL Cholesterol
HDL Cholesterol
Purification
purification
serum
Erythritol
Isosorbide
food
Hypercholesterolemia
Serum
Vasodilator Agents
Rats
Chronic Disease
Functional food
product
Therapeutics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Medicine(all)

Cite this

Hypocholesterolemic activity of Monascus fermented product in the absence of monacolins with partial purification for functional food applications. / Ajdari, Zahra; Abd. Ghani, Ma`Aruf; Ayob, Mohd. Khan; Bayat, Saadi; Mokhtar, Mazlin; Abbasiliasi, Sahar; Khoramnia, Anahita; Rahman, Heshu Sulaiman; Mehrbod, Parvaneh; Ajdari, Daniel; Ariff, Arbakariya B.

In: The Scientific World Journal, Vol. 2014, 252647, 2014.

Research output: Contribution to journalArticle

Ajdari, Zahra ; Abd. Ghani, Ma`Aruf ; Ayob, Mohd. Khan ; Bayat, Saadi ; Mokhtar, Mazlin ; Abbasiliasi, Sahar ; Khoramnia, Anahita ; Rahman, Heshu Sulaiman ; Mehrbod, Parvaneh ; Ajdari, Daniel ; Ariff, Arbakariya B. / Hypocholesterolemic activity of Monascus fermented product in the absence of monacolins with partial purification for functional food applications. In: The Scientific World Journal. 2014 ; Vol. 2014.
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