Abstract
Hypercholesterolemia is one of the most common chronic diseases in human. Along with chemical therapy traditional medication is used as hypocholesterolemic remedy, however, with unfavorable side effects. Recently, Monascus fermented product (MFP) has become a popular hypocholesterolemic natural supplement. In the present study, the hypocholesterolemic activity of Monascus purpureus FTC5391 fermented product ethanolic extract (MFPe) was investigated in hypercholesterolemic rats. Results showed that MFPe not only reduced the serum total cholesterol (TC), LDL-C, TG concentration, and TC/HDL-C ratio but also increased the HDL-C. Further, solid phase extraction (SPE) was carried out to obtain the hypocholesterolemic bioactive fraction. The high polar fraction of SPE increased the HDL-C (42%) and decreased the TC (53.3%), LDL-C (47%), and TG (50.7%) levels as well as TC/HDL-C ratio (69.1%) in serum. The GC-MS results of the active fraction revealed two main compounds, isosorbide and erythritol, which act as coronary vasodilator compounds.
| Original language | English |
|---|---|
| Article number | 252647 |
| Journal | The Scientific World Journal |
| Volume | 2014 |
| DOIs | |
| Publication status | Published - 2014 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Environmental Science(all)
- Medicine(all)
Cite this
Hypocholesterolemic activity of Monascus fermented product in the absence of monacolins with partial purification for functional food applications. / Ajdari, Zahra; Abd. Ghani, Ma`Aruf; Ayob, Mohd. Khan; Bayat, Saadi; Mokhtar, Mazlin; Abbasiliasi, Sahar; Khoramnia, Anahita; Rahman, Heshu Sulaiman; Mehrbod, Parvaneh; Ajdari, Daniel; Ariff, Arbakariya B.
In: The Scientific World Journal, Vol. 2014, 252647, 2014.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hypocholesterolemic activity of Monascus fermented product in the absence of monacolins with partial purification for functional food applications
AU - Ajdari, Zahra
AU - Abd. Ghani, Ma`Aruf
AU - Ayob, Mohd. Khan
AU - Bayat, Saadi
AU - Mokhtar, Mazlin
AU - Abbasiliasi, Sahar
AU - Khoramnia, Anahita
AU - Rahman, Heshu Sulaiman
AU - Mehrbod, Parvaneh
AU - Ajdari, Daniel
AU - Ariff, Arbakariya B.
PY - 2014
Y1 - 2014
N2 - Hypercholesterolemia is one of the most common chronic diseases in human. Along with chemical therapy traditional medication is used as hypocholesterolemic remedy, however, with unfavorable side effects. Recently, Monascus fermented product (MFP) has become a popular hypocholesterolemic natural supplement. In the present study, the hypocholesterolemic activity of Monascus purpureus FTC5391 fermented product ethanolic extract (MFPe) was investigated in hypercholesterolemic rats. Results showed that MFPe not only reduced the serum total cholesterol (TC), LDL-C, TG concentration, and TC/HDL-C ratio but also increased the HDL-C. Further, solid phase extraction (SPE) was carried out to obtain the hypocholesterolemic bioactive fraction. The high polar fraction of SPE increased the HDL-C (42%) and decreased the TC (53.3%), LDL-C (47%), and TG (50.7%) levels as well as TC/HDL-C ratio (69.1%) in serum. The GC-MS results of the active fraction revealed two main compounds, isosorbide and erythritol, which act as coronary vasodilator compounds.
AB - Hypercholesterolemia is one of the most common chronic diseases in human. Along with chemical therapy traditional medication is used as hypocholesterolemic remedy, however, with unfavorable side effects. Recently, Monascus fermented product (MFP) has become a popular hypocholesterolemic natural supplement. In the present study, the hypocholesterolemic activity of Monascus purpureus FTC5391 fermented product ethanolic extract (MFPe) was investigated in hypercholesterolemic rats. Results showed that MFPe not only reduced the serum total cholesterol (TC), LDL-C, TG concentration, and TC/HDL-C ratio but also increased the HDL-C. Further, solid phase extraction (SPE) was carried out to obtain the hypocholesterolemic bioactive fraction. The high polar fraction of SPE increased the HDL-C (42%) and decreased the TC (53.3%), LDL-C (47%), and TG (50.7%) levels as well as TC/HDL-C ratio (69.1%) in serum. The GC-MS results of the active fraction revealed two main compounds, isosorbide and erythritol, which act as coronary vasodilator compounds.
UR - http://www.scopus.com/inward/record.url?scp=84896337285&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84896337285&partnerID=8YFLogxK
U2 - 10.1155/2014/252647
DO - 10.1155/2014/252647
M3 - Article
C2 - 24701147
AN - SCOPUS:84896337285
VL - 2014
JO - Scientific World Journal
JF - Scientific World Journal
SN - 2356-6140
M1 - 252647
ER -