Hypoactive sexual desire among depressed female patients treated with selective serotonin reuptake inhibitors

A comparison between escitalopram and fluoxetine

Hatta Sidi, Duni Asmidar, Rozita Hod, Nik Ruzyanei Nik Jaafar, Ng Chong Guan

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective. To determine the risk of hypoactive sexual desire (HSD) in depressed female patients treated with selective serotonin reuptake inhibitors, comparing escitalopram and fluoxetine. The associated factors were also examined. Methods. This cross-sectional study involved 112 female patients (56 in each group) diagnosed to have major depressive disorder who were in remission (as defined by the Diagnostic and Statistical Manual-IV (DSM-IV) in the past 2 months and the MontgomeryAsberg Depression Rating Scale (MADRS) score of ≤ 10) from the psychiatric clinic, University Kebangsaan Malaysia Medical Centre (UKMMC). They were interviewed using the Structured Clinical Interview for DSM-IV (SCID). Hypoactive sexual desire was assessed using the Desire subscale of the Malay Version of the Female Sexual Function Index (MVFSFI). Results. The risk of hypoactive sexual desire was 50.9% for all patients; 64.3% for the fluoxetine group and 37.5% for the escitalopram group. Multivariate logistic regression analysis showed fluoxetine therapy (adjusted OR = 3.08, CI = 1.23, 7.73) and moderate to high dosage of antidepressant (adjusted OR = 4.27, CI = 1.66, 10.95) were significantly associated with hypoactive sexual desire. Conclusion. Those treated with fluoxetine had significantly higher rates of HSD than those on escitalopram. Moderate to high antidepressant dosage is another significant predictor of HSD in depressed women treated with SSRIs.

Original languageEnglish
Pages (from-to)41-47
Number of pages7
JournalInternational Journal of Psychiatry in Clinical Practice
Volume16
Issue number1
DOIs
Publication statusPublished - Mar 2012

Fingerprint

Citalopram
Fluoxetine
Serotonin Uptake Inhibitors
Antidepressive Agents
Malaysia
Major Depressive Disorder
Psychiatry
Cross-Sectional Studies
Logistic Models
Regression Analysis
Interviews
Depression
Therapeutics

Keywords

  • Depression
  • Escitalopram
  • Female
  • Fluoxetine
  • Hypoactive sexual desire

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

@article{ddcb8e9ded544844b422a1fca53666db,
title = "Hypoactive sexual desire among depressed female patients treated with selective serotonin reuptake inhibitors: A comparison between escitalopram and fluoxetine",
abstract = "Objective. To determine the risk of hypoactive sexual desire (HSD) in depressed female patients treated with selective serotonin reuptake inhibitors, comparing escitalopram and fluoxetine. The associated factors were also examined. Methods. This cross-sectional study involved 112 female patients (56 in each group) diagnosed to have major depressive disorder who were in remission (as defined by the Diagnostic and Statistical Manual-IV (DSM-IV) in the past 2 months and the MontgomeryAsberg Depression Rating Scale (MADRS) score of ≤ 10) from the psychiatric clinic, University Kebangsaan Malaysia Medical Centre (UKMMC). They were interviewed using the Structured Clinical Interview for DSM-IV (SCID). Hypoactive sexual desire was assessed using the Desire subscale of the Malay Version of the Female Sexual Function Index (MVFSFI). Results. The risk of hypoactive sexual desire was 50.9{\%} for all patients; 64.3{\%} for the fluoxetine group and 37.5{\%} for the escitalopram group. Multivariate logistic regression analysis showed fluoxetine therapy (adjusted OR = 3.08, CI = 1.23, 7.73) and moderate to high dosage of antidepressant (adjusted OR = 4.27, CI = 1.66, 10.95) were significantly associated with hypoactive sexual desire. Conclusion. Those treated with fluoxetine had significantly higher rates of HSD than those on escitalopram. Moderate to high antidepressant dosage is another significant predictor of HSD in depressed women treated with SSRIs.",
keywords = "Depression, Escitalopram, Female, Fluoxetine, Hypoactive sexual desire",
author = "Hatta Sidi and Duni Asmidar and Rozita Hod and {Nik Jaafar}, {Nik Ruzyanei} and Guan, {Ng Chong}",
year = "2012",
month = "3",
doi = "10.3109/13651501.2011.617457",
language = "English",
volume = "16",
pages = "41--47",
journal = "International Journal of Psychiatry in Clinical Practice",
issn = "1365-1501",
publisher = "Informa Healthcare",
number = "1",

}

TY - JOUR

T1 - Hypoactive sexual desire among depressed female patients treated with selective serotonin reuptake inhibitors

T2 - A comparison between escitalopram and fluoxetine

AU - Sidi, Hatta

AU - Asmidar, Duni

AU - Hod, Rozita

AU - Nik Jaafar, Nik Ruzyanei

AU - Guan, Ng Chong

PY - 2012/3

Y1 - 2012/3

N2 - Objective. To determine the risk of hypoactive sexual desire (HSD) in depressed female patients treated with selective serotonin reuptake inhibitors, comparing escitalopram and fluoxetine. The associated factors were also examined. Methods. This cross-sectional study involved 112 female patients (56 in each group) diagnosed to have major depressive disorder who were in remission (as defined by the Diagnostic and Statistical Manual-IV (DSM-IV) in the past 2 months and the MontgomeryAsberg Depression Rating Scale (MADRS) score of ≤ 10) from the psychiatric clinic, University Kebangsaan Malaysia Medical Centre (UKMMC). They were interviewed using the Structured Clinical Interview for DSM-IV (SCID). Hypoactive sexual desire was assessed using the Desire subscale of the Malay Version of the Female Sexual Function Index (MVFSFI). Results. The risk of hypoactive sexual desire was 50.9% for all patients; 64.3% for the fluoxetine group and 37.5% for the escitalopram group. Multivariate logistic regression analysis showed fluoxetine therapy (adjusted OR = 3.08, CI = 1.23, 7.73) and moderate to high dosage of antidepressant (adjusted OR = 4.27, CI = 1.66, 10.95) were significantly associated with hypoactive sexual desire. Conclusion. Those treated with fluoxetine had significantly higher rates of HSD than those on escitalopram. Moderate to high antidepressant dosage is another significant predictor of HSD in depressed women treated with SSRIs.

AB - Objective. To determine the risk of hypoactive sexual desire (HSD) in depressed female patients treated with selective serotonin reuptake inhibitors, comparing escitalopram and fluoxetine. The associated factors were also examined. Methods. This cross-sectional study involved 112 female patients (56 in each group) diagnosed to have major depressive disorder who were in remission (as defined by the Diagnostic and Statistical Manual-IV (DSM-IV) in the past 2 months and the MontgomeryAsberg Depression Rating Scale (MADRS) score of ≤ 10) from the psychiatric clinic, University Kebangsaan Malaysia Medical Centre (UKMMC). They were interviewed using the Structured Clinical Interview for DSM-IV (SCID). Hypoactive sexual desire was assessed using the Desire subscale of the Malay Version of the Female Sexual Function Index (MVFSFI). Results. The risk of hypoactive sexual desire was 50.9% for all patients; 64.3% for the fluoxetine group and 37.5% for the escitalopram group. Multivariate logistic regression analysis showed fluoxetine therapy (adjusted OR = 3.08, CI = 1.23, 7.73) and moderate to high dosage of antidepressant (adjusted OR = 4.27, CI = 1.66, 10.95) were significantly associated with hypoactive sexual desire. Conclusion. Those treated with fluoxetine had significantly higher rates of HSD than those on escitalopram. Moderate to high antidepressant dosage is another significant predictor of HSD in depressed women treated with SSRIs.

KW - Depression

KW - Escitalopram

KW - Female

KW - Fluoxetine

KW - Hypoactive sexual desire

UR - http://www.scopus.com/inward/record.url?scp=84856840062&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84856840062&partnerID=8YFLogxK

U2 - 10.3109/13651501.2011.617457

DO - 10.3109/13651501.2011.617457

M3 - Article

VL - 16

SP - 41

EP - 47

JO - International Journal of Psychiatry in Clinical Practice

JF - International Journal of Psychiatry in Clinical Practice

SN - 1365-1501

IS - 1

ER -