Hydrothermal synthesis of magnetite nanoparticles as MRI contrast agents

C. Y. Haw, Faizal K.P. Kunchi Mohamed, Chin Hua Chia, Shahidan Radiman, Sarani Zakaria, N. M. Huang, H. N. Lim

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

Magnetite (Fe3O4) nanoparticles prepared using hydrothermal approach were employed to study their potential application as magnetic resonance imaging (MRI) contrast agent. The hydrothermal process involves precursors FeCl2·4H2O and FeCl3 with NaOH as reducing agent to initiate the precipitation of Fe3O4, followed by hydrothermal treatment to produce nano-sized Fe3O4. Chitosan (CTS) was coated onto the surface of the as-prepared Fe3O4 nanoparticles to enhance its stability and biocompatible properties. The size distribution of the obtained Fe3O4 nanoparticles was examined using transmission electron microscopy (TEM). The cubic inverse spinel structure of Fe3O4 nanoparticles was confirmed by X-ray diffraction technique (XRD). Fourier transform infrared (FTIR) spectrum indicated the presence of the chitosan on the surface of the Fe3O4 nanoparticles. The superparamagnetic behaviour of the produced Fe3O4 nanoparticles at room temperature was elucidated using a vibrating sample magnetometer (VSM). From the result of custom made phantom study of magnetic resonance (MR) imaging, coated Fe3O4 nanoparticles have been proved to be a promising contrast enhanced agent in MR imaging.

Original languageEnglish
Pages (from-to)1417-1422
Number of pages6
JournalCeramics International
Volume36
Issue number4
DOIs
Publication statusPublished - May 2010

Fingerprint

Magnetite Nanoparticles
Magnetite nanoparticles
Hydrothermal synthesis
Magnetic resonance
Contrast Media
Nanoparticles
Imaging techniques
Chitosan
Reducing Agents
Reducing agents
Magnetometers
Fourier transforms
Transmission electron microscopy
Infrared radiation
X ray diffraction

Keywords

  • B. Surfaces
  • C. Magnetic properties
  • E. Biomedical applications
  • Hydrothermal

ASJC Scopus subject areas

  • Ceramics and Composites
  • Process Chemistry and Technology
  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films
  • Materials Chemistry

Cite this

Hydrothermal synthesis of magnetite nanoparticles as MRI contrast agents. / Haw, C. Y.; K.P. Kunchi Mohamed, Faizal; Chia, Chin Hua; Radiman, Shahidan; Zakaria, Sarani; Huang, N. M.; Lim, H. N.

In: Ceramics International, Vol. 36, No. 4, 05.2010, p. 1417-1422.

Research output: Contribution to journalArticle

Haw, C. Y. ; K.P. Kunchi Mohamed, Faizal ; Chia, Chin Hua ; Radiman, Shahidan ; Zakaria, Sarani ; Huang, N. M. ; Lim, H. N. / Hydrothermal synthesis of magnetite nanoparticles as MRI contrast agents. In: Ceramics International. 2010 ; Vol. 36, No. 4. pp. 1417-1422.
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