Hydrophobic kenaf nanocrystalline cellulose for the binding of curcumin

Norhidayu Zainuddin, Ishak Ahmad, Hanieh Kargarzadeh, Suria Ramli

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Nanocrystalline cellulose (NCC) extracted from lignocellulosic materials has been actively investigated as a drug delivery excipients due to its large surface area, high aspect ratio, and biodegradability. In this study, the hydrophobically modified NCC was used as a drug delivery excipient of hydrophobic drug curcumin. The modification of NCC with a cationic surfactant, cetyl trimethylammonium bromide (CTAB) was used to modulate the loading of hydrophobic drugs that would not normally bind to NCC. The FTIR, Elemental analysis, XRD, TGA, and TEM were used to confirm the modification of NCC with CTAB. The effect of concentration of CTAB on the binding efficiency of hydrophobic drug curcumin was investigated. The amounts of curcumin bound onto the CTAB–NCC nanoparticles were analyzed by UV–vis Spectrophotometric. The result showed that the modified CTAB–NCC bound a significant amount of curcumin, in a range from 80% to 96% curcumin added. Nevertheless, at higher concentration of CTAB resulted in lower binding efficiency.

Original languageEnglish
Pages (from-to)261-269
Number of pages9
JournalCarbohydrate Polymers
Volume163
DOIs
Publication statusPublished - 1 May 2017

Fingerprint

Curcumin
Cellulose
Bromides
Excipients
Drug delivery
Pharmaceutical Preparations
Cationic surfactants
Biodegradability
Aspect ratio
Nanoparticles
Transmission electron microscopy
Chemical analysis

Keywords

  • Cetyl trimethylammonium bromide
  • Curcumin
  • Drug delivery
  • Hydrophobic NCC
  • Nanocrystalline cellulose
  • Surface modification

ASJC Scopus subject areas

  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry

Cite this

Hydrophobic kenaf nanocrystalline cellulose for the binding of curcumin. / Zainuddin, Norhidayu; Ahmad, Ishak; Kargarzadeh, Hanieh; Ramli, Suria.

In: Carbohydrate Polymers, Vol. 163, 01.05.2017, p. 261-269.

Research output: Contribution to journalArticle

Zainuddin, Norhidayu ; Ahmad, Ishak ; Kargarzadeh, Hanieh ; Ramli, Suria. / Hydrophobic kenaf nanocrystalline cellulose for the binding of curcumin. In: Carbohydrate Polymers. 2017 ; Vol. 163. pp. 261-269.
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