Hydrogen peroxide scavenging activity of novel coumarins synthesized using different approaches

Ahmed A. Al-Amiery, Yasameen K. Al-Majedy, Abdul Amir H. Kadhum, Abu Bakar Mohamad

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

New derivatives of 7-hydroxy-4-methylcoumarin were synthesized using a chemical method and a microwave-assisted method to compare the feasibility, reaction times, and yields of the product. The newly synthesized coumarins were characterized by different spectroscopic techniques (FT-IR and NMR) and micro-elemental analysis (CHNS). In vitro antioxidant activities of these compounds were evaluated against hydrogen peroxide and were compared with standard natural antioxidant, vitamin C. Our results reveal that these compounds exhibit excellent radical scavenging activities.

Original languageEnglish
Article numbere0132175
JournalPLoS One
Volume10
Issue number7
DOIs
Publication statusPublished - 6 Jul 2015

Fingerprint

Coumarins
coumarins
Scavenging
Hydrogen Peroxide
hydrogen peroxide
Antioxidants
Microwaves
Ascorbic Acid
Nuclear magnetic resonance
Derivatives
antioxidant activity
ascorbic acid
chemical derivatives
Chemical analysis
methodology
antioxidants
7-hydroxy-4-methylcoumarin
In Vitro Techniques

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Al-Amiery, A. A., Al-Majedy, Y. K., Kadhum, A. A. H., & Mohamad, A. B. (2015). Hydrogen peroxide scavenging activity of novel coumarins synthesized using different approaches. PLoS One, 10(7), [e0132175]. https://doi.org/10.1371/journal.pone.0132175

Hydrogen peroxide scavenging activity of novel coumarins synthesized using different approaches. / Al-Amiery, Ahmed A.; Al-Majedy, Yasameen K.; Kadhum, Abdul Amir H.; Mohamad, Abu Bakar.

In: PLoS One, Vol. 10, No. 7, e0132175, 06.07.2015.

Research output: Contribution to journalArticle

Al-Amiery, Ahmed A. ; Al-Majedy, Yasameen K. ; Kadhum, Abdul Amir H. ; Mohamad, Abu Bakar. / Hydrogen peroxide scavenging activity of novel coumarins synthesized using different approaches. In: PLoS One. 2015 ; Vol. 10, No. 7.
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