Hidrogel bersifat peka terhadap rangsangan suhu untuk penjerapan dan pembebasan dadah

Translated title of the contribution: Hydrogel with thermo-responsive behavior for drug adsorption and release

Teow Yeit Haan, Kushalini Rames

Research output: Contribution to journalArticle

Abstract

In this study, hydrogel with thermo-responsive behavior was synthesized as a medium for drug delivery. Performance of synthesized hydrogel was studied using a different percentage of citric acid at 5%, 10%, and 15%. The use of a large amount of citric acid leads to a strong polymer bond, thus increasing the percentage of O-H functional group subsenquently hydrophilicity of hydrogel. Therefore, polar aspirin molecules with functional group of carboxylic acid are more likely to be adsorbed on the surface of the hydrogel synthesized using 15% citric acid via hydrogen bonding. In addition, dense polymer chain is more responsive to temperature change. Hence, hydrogel synthesized using 15% citric acid is more effective to release the adsorbed aspirin molecules. In the drug adsorption and release study, the results achieved were fitted closely with the Langmuir model and the Pseudo first kinetic model. Langmuir model implied that aspirin adsorption involves only one layer on the surface of the hydrogel. After adsorption occurs on the hydrogel surface, no further assorption will occur. While the Pseudo first kinetic model supported that the adsorption occurs through physical mechanisms where aspirin molecules will be adsorbed on the surface of the hydrogel without the occurrence of reaction.

Original languageMalay
Pages (from-to)390-400
Number of pages11
JournalMalaysian Journal of Analytical Sciences
Volume23
Issue number3
DOIs
Publication statusPublished - 1 Jan 2019

Fingerprint

Hydrogel
Adsorption
Citric Acid
Pharmaceutical Preparations
Aspirin
Functional groups
Molecules
Polymers
Kinetics
Hydrophilicity
Carboxylic Acids
Drug delivery
Hydrogen bonds

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Hidrogel bersifat peka terhadap rangsangan suhu untuk penjerapan dan pembebasan dadah. / Yeit Haan, Teow; Rames, Kushalini.

In: Malaysian Journal of Analytical Sciences, Vol. 23, No. 3, 01.01.2019, p. 390-400.

Research output: Contribution to journalArticle

@article{ad701d9bd38246468909f0666546b638,
title = "Hidrogel bersifat peka terhadap rangsangan suhu untuk penjerapan dan pembebasan dadah",
abstract = "In this study, hydrogel with thermo-responsive behavior was synthesized as a medium for drug delivery. Performance of synthesized hydrogel was studied using a different percentage of citric acid at 5{\%}, 10{\%}, and 15{\%}. The use of a large amount of citric acid leads to a strong polymer bond, thus increasing the percentage of O-H functional group subsenquently hydrophilicity of hydrogel. Therefore, polar aspirin molecules with functional group of carboxylic acid are more likely to be adsorbed on the surface of the hydrogel synthesized using 15{\%} citric acid via hydrogen bonding. In addition, dense polymer chain is more responsive to temperature change. Hence, hydrogel synthesized using 15{\%} citric acid is more effective to release the adsorbed aspirin molecules. In the drug adsorption and release study, the results achieved were fitted closely with the Langmuir model and the Pseudo first kinetic model. Langmuir model implied that aspirin adsorption involves only one layer on the surface of the hydrogel. After adsorption occurs on the hydrogel surface, no further assorption will occur. While the Pseudo first kinetic model supported that the adsorption occurs through physical mechanisms where aspirin molecules will be adsorbed on the surface of the hydrogel without the occurrence of reaction.",
keywords = "Body temperature, Drug adsorption, Drug release, Hydrogel, Thermo-responsive",
author = "{Yeit Haan}, Teow and Kushalini Rames",
year = "2019",
month = "1",
day = "1",
doi = "10.17576/mjas-2019-2303-03",
language = "Malay",
volume = "23",
pages = "390--400",
journal = "Malaysian Journal of Analytical Sciences",
issn = "1394-2506",
publisher = "Faculty of Science and Technology, Universiti Kebangsaan Malaysia",
number = "3",

}

TY - JOUR

T1 - Hidrogel bersifat peka terhadap rangsangan suhu untuk penjerapan dan pembebasan dadah

AU - Yeit Haan, Teow

AU - Rames, Kushalini

PY - 2019/1/1

Y1 - 2019/1/1

N2 - In this study, hydrogel with thermo-responsive behavior was synthesized as a medium for drug delivery. Performance of synthesized hydrogel was studied using a different percentage of citric acid at 5%, 10%, and 15%. The use of a large amount of citric acid leads to a strong polymer bond, thus increasing the percentage of O-H functional group subsenquently hydrophilicity of hydrogel. Therefore, polar aspirin molecules with functional group of carboxylic acid are more likely to be adsorbed on the surface of the hydrogel synthesized using 15% citric acid via hydrogen bonding. In addition, dense polymer chain is more responsive to temperature change. Hence, hydrogel synthesized using 15% citric acid is more effective to release the adsorbed aspirin molecules. In the drug adsorption and release study, the results achieved were fitted closely with the Langmuir model and the Pseudo first kinetic model. Langmuir model implied that aspirin adsorption involves only one layer on the surface of the hydrogel. After adsorption occurs on the hydrogel surface, no further assorption will occur. While the Pseudo first kinetic model supported that the adsorption occurs through physical mechanisms where aspirin molecules will be adsorbed on the surface of the hydrogel without the occurrence of reaction.

AB - In this study, hydrogel with thermo-responsive behavior was synthesized as a medium for drug delivery. Performance of synthesized hydrogel was studied using a different percentage of citric acid at 5%, 10%, and 15%. The use of a large amount of citric acid leads to a strong polymer bond, thus increasing the percentage of O-H functional group subsenquently hydrophilicity of hydrogel. Therefore, polar aspirin molecules with functional group of carboxylic acid are more likely to be adsorbed on the surface of the hydrogel synthesized using 15% citric acid via hydrogen bonding. In addition, dense polymer chain is more responsive to temperature change. Hence, hydrogel synthesized using 15% citric acid is more effective to release the adsorbed aspirin molecules. In the drug adsorption and release study, the results achieved were fitted closely with the Langmuir model and the Pseudo first kinetic model. Langmuir model implied that aspirin adsorption involves only one layer on the surface of the hydrogel. After adsorption occurs on the hydrogel surface, no further assorption will occur. While the Pseudo first kinetic model supported that the adsorption occurs through physical mechanisms where aspirin molecules will be adsorbed on the surface of the hydrogel without the occurrence of reaction.

KW - Body temperature

KW - Drug adsorption

KW - Drug release

KW - Hydrogel

KW - Thermo-responsive

UR - http://www.scopus.com/inward/record.url?scp=85069201184&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85069201184&partnerID=8YFLogxK

U2 - 10.17576/mjas-2019-2303-03

DO - 10.17576/mjas-2019-2303-03

M3 - Article

AN - SCOPUS:85069201184

VL - 23

SP - 390

EP - 400

JO - Malaysian Journal of Analytical Sciences

JF - Malaysian Journal of Analytical Sciences

SN - 1394-2506

IS - 3

ER -