Hydrogel-forming microneedle arrays for enhanced transdermal drug delivery

Ryan F. Donnelly, Thakur Raghu Raj Singh, Martin J. Garland, Katarzyna Migalska, Rita Majithiya, Cian M. McCrudden, Prashant Laxman Kole, Tuan Mazlelaa Tuan Mahmood, Helen O. McCarthy, A. David Woolfson

Research output: Contribution to journalArticle

153 Citations (Scopus)

Abstract

Unique microneedle arrays prepared from crosslinked polymers, which contain no drug themselves, are described. They rapidly take up skin interstitial fluid upon skin insertion to form continuous, unblockable, hydrogel conduits from attached patch-type drug reservoirs to the dermal microcirculation. Importantly, such microneedles, which can be fabricated in a wide range of patch sizes and microneedle geometries, can be easily sterilized, resist hole closure while in place, and are removed completely intact from the skin. Delivery of macromolecules is no longer limited to what can be loaded into the microneedles themselves and transdermal drug delivery is now controlled by the crosslink density of the hydrogel system rather than the stratum corneum, while electrically modulated delivery is also a unique feature. This technology has the potential to overcome the limitations of conventional microneedle designs and greatly increase the range of the type of drug that is deliverable transdermally, with ensuing benefits for industry, healthcare providers and, ultimately, patients.

Original languageEnglish
Pages (from-to)4879-4890
Number of pages12
JournalAdvanced Functional Materials
Volume22
Issue number23
DOIs
Publication statusPublished - 5 Dec 2012
Externally publishedYes

Fingerprint

Hydrogel
Drug delivery
Hydrogels
delivery
Skin
drugs
Pharmaceutical Preparations
Microcirculation
Macromolecules
cornea
Polymers
strata
macromolecules
closures
insertion
interstitials
Fluids
Geometry
industries
fluids

Keywords

  • biocompatibility
  • drug delivery
  • hydrogels
  • microneedles
  • safety

ASJC Scopus subject areas

  • Biomaterials
  • Electrochemistry
  • Condensed Matter Physics
  • Electronic, Optical and Magnetic Materials

Cite this

Donnelly, R. F., Singh, T. R. R., Garland, M. J., Migalska, K., Majithiya, R., McCrudden, C. M., ... Woolfson, A. D. (2012). Hydrogel-forming microneedle arrays for enhanced transdermal drug delivery. Advanced Functional Materials, 22(23), 4879-4890. https://doi.org/10.1002/adfm.201200864

Hydrogel-forming microneedle arrays for enhanced transdermal drug delivery. / Donnelly, Ryan F.; Singh, Thakur Raghu Raj; Garland, Martin J.; Migalska, Katarzyna; Majithiya, Rita; McCrudden, Cian M.; Kole, Prashant Laxman; Tuan Mahmood, Tuan Mazlelaa; McCarthy, Helen O.; Woolfson, A. David.

In: Advanced Functional Materials, Vol. 22, No. 23, 05.12.2012, p. 4879-4890.

Research output: Contribution to journalArticle

Donnelly, RF, Singh, TRR, Garland, MJ, Migalska, K, Majithiya, R, McCrudden, CM, Kole, PL, Tuan Mahmood, TM, McCarthy, HO & Woolfson, AD 2012, 'Hydrogel-forming microneedle arrays for enhanced transdermal drug delivery', Advanced Functional Materials, vol. 22, no. 23, pp. 4879-4890. https://doi.org/10.1002/adfm.201200864
Donnelly RF, Singh TRR, Garland MJ, Migalska K, Majithiya R, McCrudden CM et al. Hydrogel-forming microneedle arrays for enhanced transdermal drug delivery. Advanced Functional Materials. 2012 Dec 5;22(23):4879-4890. https://doi.org/10.1002/adfm.201200864
Donnelly, Ryan F. ; Singh, Thakur Raghu Raj ; Garland, Martin J. ; Migalska, Katarzyna ; Majithiya, Rita ; McCrudden, Cian M. ; Kole, Prashant Laxman ; Tuan Mahmood, Tuan Mazlelaa ; McCarthy, Helen O. ; Woolfson, A. David. / Hydrogel-forming microneedle arrays for enhanced transdermal drug delivery. In: Advanced Functional Materials. 2012 ; Vol. 22, No. 23. pp. 4879-4890.
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