Hybrid registration of PET/CT in thoracic region with pre-filtering PET sinogram

Siti Salasiah Mokri, M. I. Saripan, M. H. Marhaban, A. J. Nordin, S. Hashim

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The integration of physiological (PET) and anatomical (CT) images in cancer delineation requires an accurate spatial registration technique. Although hybrid PET/CT scanner is used to co-register these images, significant misregistrations exist due to patient and respiratory/cardiac motions. This paper proposes a hybrid feature-intensity based registration technique for hybrid PET/CT scanner. First, simulated PET sinogram was filtered with a 3D hybrid mean-median before reconstructing the image. The features were then derived from the segmented structures (lung, heart and tumor) from both images. The registration was performed based on modified multi-modality demon registration with multiresolution scheme. Apart from visual observations improvements, the proposed registration technique increased the normalized mutual information index (NMI) between the PET/CT images after registration. All nine tested datasets show marked improvements in mutual information (MI) index than free form deformation (FFD) registration technique with the highest MI increase is 25%.

Original languageEnglish
Pages (from-to)300-304
Number of pages5
JournalRadiation Physics and Chemistry
Volume116
DOIs
Publication statusPublished - 1 Nov 2015
Externally publishedYes

Fingerprint

scanners
visual observation
delineation
registers
lungs
tumors
cancer

Keywords

  • Hybrid demon registration
  • Multi-modalities
  • PET/CT
  • Sinogram filtering

ASJC Scopus subject areas

  • Radiation

Cite this

Hybrid registration of PET/CT in thoracic region with pre-filtering PET sinogram. / Mokri, Siti Salasiah; Saripan, M. I.; Marhaban, M. H.; Nordin, A. J.; Hashim, S.

In: Radiation Physics and Chemistry, Vol. 116, 01.11.2015, p. 300-304.

Research output: Contribution to journalArticle

Mokri, Siti Salasiah ; Saripan, M. I. ; Marhaban, M. H. ; Nordin, A. J. ; Hashim, S. / Hybrid registration of PET/CT in thoracic region with pre-filtering PET sinogram. In: Radiation Physics and Chemistry. 2015 ; Vol. 116. pp. 300-304.
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