Hyaluronic acid, a promising skin rejuvenating biomedicine

A review of recent updates and pre-clinical and clinical investigations on cosmetic and nutricosmetic effects

Bukhari Syed Nasir Abbas, Nur Liyana Roswandi, Muhammad Waqas, Haroon Habib, Fahad Hussain, Shahzeb Khan, Muhammad Sohail, Nor Amlizan Ramli, Hnin Ei Thu, Zahid Hussain

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Hyaluronic acid (HA) plays multifaceted role in regulating the various biological processes such as skin repairmen, diagnosis of cancer, wound healing, tissue regeneration, anti-inflammatory, and immunomodulation. Owing to its remarkable biomedical and tissue regeneration potential, HA has been numerously employed as one of the imperative components of the cosmetic and nutricosmetic products. The present review aims to summarize and critically appraise recent developments and clinical investigations on cosmetic and nutricosmetic efficacy of HA for skin rejuvenation. A thorough analysis of the literature revealed that HA based formulations (i.e., gels, creams, intra-dermal filler injections, dermal fillers, facial fillers, autologous fat gels, lotion, serum, and implants, etc.) exhibit remarkable anti-wrinkle, anti-nasolabial fold, anti-aging, space-filling, and face rejuvenating properties. This has been achieved via soft tissue augmentation, improved skin hydration, collagen and elastin stimulation, and face volume restoration. HA, alone or in combination with lidocaine and other co-agents, showed promising efficacy in skin tightness and elasticity, face rejuvenation, improving aesthetic scores, reducing the wrinkle scars, longevity, and tear trough rejuvenation. Our critical analysis evidenced that application/administration of HA exhibits outstanding nutricosmetic efficacy and thus is warranted to be used as a prime component of cosmetic products.

Original languageEnglish
Pages (from-to)1682-1695
Number of pages14
JournalInternational Journal of Biological Macromolecules
Volume120
DOIs
Publication statusPublished - 1 Dec 2018
Externally publishedYes

Fingerprint

Cosmetics
Hyaluronic Acid
Skin
Rejuvenation
Tissue regeneration
Regeneration
Nasolabial Fold
Gels
Biological Phenomena
Immunomodulation
Elastin
Elasticity
Lidocaine
Tears
Esthetics
Hydration
Wound Healing
Restoration
Cicatrix
Fillers

Keywords

  • Anti-aging, nasolabial folds, dermal filler
  • Anti-wrinkle
  • Face rejuvenation
  • Hyaluronic acid
  • Nutricosmetic

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Molecular Biology

Cite this

Hyaluronic acid, a promising skin rejuvenating biomedicine : A review of recent updates and pre-clinical and clinical investigations on cosmetic and nutricosmetic effects. / Syed Nasir Abbas, Bukhari; Roswandi, Nur Liyana; Waqas, Muhammad; Habib, Haroon; Hussain, Fahad; Khan, Shahzeb; Sohail, Muhammad; Ramli, Nor Amlizan; Thu, Hnin Ei; Hussain, Zahid.

In: International Journal of Biological Macromolecules, Vol. 120, 01.12.2018, p. 1682-1695.

Research output: Contribution to journalReview article

Syed Nasir Abbas, Bukhari ; Roswandi, Nur Liyana ; Waqas, Muhammad ; Habib, Haroon ; Hussain, Fahad ; Khan, Shahzeb ; Sohail, Muhammad ; Ramli, Nor Amlizan ; Thu, Hnin Ei ; Hussain, Zahid. / Hyaluronic acid, a promising skin rejuvenating biomedicine : A review of recent updates and pre-clinical and clinical investigations on cosmetic and nutricosmetic effects. In: International Journal of Biological Macromolecules. 2018 ; Vol. 120. pp. 1682-1695.
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AU - Khan, Shahzeb

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AU - Ramli, Nor Amlizan

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