HUMAN GIARDIASIS IN MALAYSIA: CORRELATION BETWEEN THE PRESENCE OF CLINICAL MANIFESTATION AND GIARDIA INTESTINALIS ASSEMBLAGE

Tengku S hahrul Anuar, Norhayati Moktar, Fatmah M d Salleh, Hesham M. Al-Mekhlafi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Clinical manifestations of giardiasis vary from asymptomatic infection to chronic diarrhea. A total of 611 stool samples from Aboriginal participants residing in Jelebu, Gerik and Temerloh States, Malaysia, ages 2 to 74 years were screened for Giardia intestinalis using microscopic examination and sequence analysis of a fragment of nested-PCR amplified triosephosphate isomerase (tpi) gene. Demographic data was collected through a structured questionnaire. tpi was successfully amplified from 98/110 samples microscopically positive for G. intestinalis, with 62 and 36 belonging to assemblage A and B, respectively. There is a significant correlation between assemblage A and symptomatic infection only in participants of < 15 years of age. In the other age group, host factors may have more effects on the presence of clinical signs and symptoms than G. intestinalis assemblage types.

Original languageEnglish
Pages (from-to)835-843
Number of pages9
JournalThe Southeast Asian journal of tropical medicine and public health
Volume46
Issue number5
Publication statusPublished - 1 Sep 2015

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Giardiasis
Giardia lamblia
Malaysia
Triose-Phosphate Isomerase
Asymptomatic Infections
Signs and Symptoms
Sequence Analysis
Diarrhea
Age Groups
Demography
Polymerase Chain Reaction
Infection
Genes

ASJC Scopus subject areas

  • Medicine(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

HUMAN GIARDIASIS IN MALAYSIA : CORRELATION BETWEEN THE PRESENCE OF CLINICAL MANIFESTATION AND GIARDIA INTESTINALIS ASSEMBLAGE. / Anuar, Tengku S hahrul; Moktar, Norhayati; Salleh, Fatmah M d; Al-Mekhlafi, Hesham M.

In: The Southeast Asian journal of tropical medicine and public health, Vol. 46, No. 5, 01.09.2015, p. 835-843.

Research output: Contribution to journalArticle

Anuar, Tengku S hahrul ; Moktar, Norhayati ; Salleh, Fatmah M d ; Al-Mekhlafi, Hesham M. / HUMAN GIARDIASIS IN MALAYSIA : CORRELATION BETWEEN THE PRESENCE OF CLINICAL MANIFESTATION AND GIARDIA INTESTINALIS ASSEMBLAGE. In: The Southeast Asian journal of tropical medicine and public health. 2015 ; Vol. 46, No. 5. pp. 835-843.
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