Honey and epithelial to mesenchymal transition in wound healing

An evidence-based review

Abid Nordin, Nur Qisya Afifah Veronica Sainik, Mohamed S. Zulfarina, Isa Naina Mohamed, Aminuddin Saim, Ruszymah Idrus

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

This review inspects all the available report on association of honey and the epithelial mesenchymal transition (EMT) event in wound healing. A systematic review of the literature was conducted to identify relevant studies on honey and EMT. The search was done in Medline via Ebscohost and Scopus database to obtained relevant articles published between 1823 and 2017. The main inclusion criteria were research articles published in English that reported changes in the EMT markers in in vitro wound healing model when subjected to honey. The literature search identified 19 potentially relevant articles, whereby 8 met the inclusion criteria. Two types of in vitro wound healing model were included, cutaneous and corneal wound. All studies reported a positive effect of honey in wound healing. In terms of EMT markers, honey was shown to upregulate mesenchymal markers and downregulated epithelial markers providing the evidence of EMT activation by honey. However, the effects on EMT varied dependent on the floral origin of the honey. This review provides good evidence that honey regulates the process of EMT and has a positive impact on wound healing.

Original languageEnglish
Pages (from-to)8-20
Number of pages13
JournalWound Medicine
Volume18
DOIs
Publication statusPublished - 1 Sep 2017

Fingerprint

Epithelial-Mesenchymal Transition
Honey
Wound Healing
Up-Regulation
Down-Regulation
Databases
Skin
Wounds and Injuries
Research

Keywords

  • Epithelial
  • Honey
  • Mesenchymal
  • Wound healing

ASJC Scopus subject areas

  • Surgery

Cite this

Honey and epithelial to mesenchymal transition in wound healing : An evidence-based review. / Nordin, Abid; Sainik, Nur Qisya Afifah Veronica; Zulfarina, Mohamed S.; Naina Mohamed, Isa; Saim, Aminuddin; Idrus, Ruszymah.

In: Wound Medicine, Vol. 18, 01.09.2017, p. 8-20.

Research output: Contribution to journalReview article

Nordin, Abid ; Sainik, Nur Qisya Afifah Veronica ; Zulfarina, Mohamed S. ; Naina Mohamed, Isa ; Saim, Aminuddin ; Idrus, Ruszymah. / Honey and epithelial to mesenchymal transition in wound healing : An evidence-based review. In: Wound Medicine. 2017 ; Vol. 18. pp. 8-20.
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