HLA-DQ A1, -DQB1 AND -DRB1 gene polymorphism - In Malay Type 1 diabetes mellitus patients and their use for risk prediction

A. G. Rohana, K. C. Loh, S. K. Tin, C. H. Soh, W. M Wan Nazaimoon, K. Y. Fong, Nor Azmi Kamaruddin, B. A K Khalid

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

HLA-DQA1, -DQB1, and -DRB1 gene polymorphism were analyzed to study type 1 DM susceptibility in Malay patients from Southeast Asia (Malaysia and Singapore). Patients showed significant increases in the occurrence of DQA1*0501 (50.7% vs. 20.4%; RR = 3.97; Pc < 0.01), DQB1*0201 (48% vs. 19.1%; RR = 3.86; Pc < 0.05), and DRB1*0301 (38.7 vs. 6.8%; RR = 8.36; 95% Pc < 0.05). Conversely, significant decreases were noted in the occurrence of DQA1*0601 (14.7% vs. 35.2%; RR = 0.33; Pc = 0.008) and DQB1*0601 (4% vs. 23.5%; RR = 0.16; Pc < 0.05) in type 1 DM patients. Using a logistic regression model, we derived a risk prediction model for type 1 DM in our indigenous Malay population based on the identified HLA genotypes. The RR for type 1 DM increases by a factor of 5.68 for every unit increase in the number of DRB1*0301 allele (P < 0.001), and decreases by a factor of 0.18 per unit increase in the number of DQB1*0601 allele (P < 0.001). After adjusting for these two HLA genotypes, DQA1*0501, DQB1*0201 and DQA1*0601 were not statistically significant as risk predictors. The lower incidence of type 1 DM in the Malay population may be contributed by the genotypic combinations of DR and DQ genes as well as the linkage disequilibria between susceptible and protective alleles.

Original languageEnglish
Pages (from-to)133-137
Number of pages5
JournalMedical Journal of Malaysia
Volume66
Issue number2
Publication statusPublished - Jun 2011

Fingerprint

HLA-A1 Antigen
HLA-DQ Antigens
Type 1 Diabetes Mellitus
Alleles
Logistic Models
Genotype
Genes
Malaysia
Singapore
Linkage Disequilibrium
Population Groups
Incidence
Population
HLA-DQA1 antigen

Keywords

  • Genetics
  • HLA-DQ alleles
  • HLA-DR alleles
  • Malay
  • Type 1 diabetes mellitus

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Rohana, A. G., Loh, K. C., Tin, S. K., Soh, C. H., Nazaimoon, W. M. W., Fong, K. Y., ... Khalid, B. A. K. (2011). HLA-DQ A1, -DQB1 AND -DRB1 gene polymorphism - In Malay Type 1 diabetes mellitus patients and their use for risk prediction. Medical Journal of Malaysia, 66(2), 133-137.

HLA-DQ A1, -DQB1 AND -DRB1 gene polymorphism - In Malay Type 1 diabetes mellitus patients and their use for risk prediction. / Rohana, A. G.; Loh, K. C.; Tin, S. K.; Soh, C. H.; Nazaimoon, W. M Wan; Fong, K. Y.; Kamaruddin, Nor Azmi; Khalid, B. A K.

In: Medical Journal of Malaysia, Vol. 66, No. 2, 06.2011, p. 133-137.

Research output: Contribution to journalArticle

Rohana, AG, Loh, KC, Tin, SK, Soh, CH, Nazaimoon, WMW, Fong, KY, Kamaruddin, NA & Khalid, BAK 2011, 'HLA-DQ A1, -DQB1 AND -DRB1 gene polymorphism - In Malay Type 1 diabetes mellitus patients and their use for risk prediction', Medical Journal of Malaysia, vol. 66, no. 2, pp. 133-137.
Rohana, A. G. ; Loh, K. C. ; Tin, S. K. ; Soh, C. H. ; Nazaimoon, W. M Wan ; Fong, K. Y. ; Kamaruddin, Nor Azmi ; Khalid, B. A K. / HLA-DQ A1, -DQB1 AND -DRB1 gene polymorphism - In Malay Type 1 diabetes mellitus patients and their use for risk prediction. In: Medical Journal of Malaysia. 2011 ; Vol. 66, No. 2. pp. 133-137.
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abstract = "HLA-DQA1, -DQB1, and -DRB1 gene polymorphism were analyzed to study type 1 DM susceptibility in Malay patients from Southeast Asia (Malaysia and Singapore). Patients showed significant increases in the occurrence of DQA1*0501 (50.7{\%} vs. 20.4{\%}; RR = 3.97; Pc < 0.01), DQB1*0201 (48{\%} vs. 19.1{\%}; RR = 3.86; Pc < 0.05), and DRB1*0301 (38.7 vs. 6.8{\%}; RR = 8.36; 95{\%} Pc < 0.05). Conversely, significant decreases were noted in the occurrence of DQA1*0601 (14.7{\%} vs. 35.2{\%}; RR = 0.33; Pc = 0.008) and DQB1*0601 (4{\%} vs. 23.5{\%}; RR = 0.16; Pc < 0.05) in type 1 DM patients. Using a logistic regression model, we derived a risk prediction model for type 1 DM in our indigenous Malay population based on the identified HLA genotypes. The RR for type 1 DM increases by a factor of 5.68 for every unit increase in the number of DRB1*0301 allele (P < 0.001), and decreases by a factor of 0.18 per unit increase in the number of DQB1*0601 allele (P < 0.001). After adjusting for these two HLA genotypes, DQA1*0501, DQB1*0201 and DQA1*0601 were not statistically significant as risk predictors. The lower incidence of type 1 DM in the Malay population may be contributed by the genotypic combinations of DR and DQ genes as well as the linkage disequilibria between susceptible and protective alleles.",
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