HLA antigens in Malay patients with systemic lupus erythematosus

N. C T Kong, B. A. Nasruruddin, S. Murad, K. J. Ong, K. D. Sukumaran

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Abstract

    Many studies have shown an association between human leucocyte antigens (HLA) and systemic lupus erythematosus (SLE) in the various study populations. Although SLE is not an uncommon disease in the Malaysian Archipelago, and appears to affect all three major racial groups equally (i.e. Southern Chinese, Malays and Southern Indians), very little information is available on the HLA profiles in the two latter groups. In phase I of our study of the HLA profiles in Malaysian SLE patients, the HLA phenotypes (class I: A, B, C; Class II: DR, DQ) of Malay patients with confirmed SLE and 91 normal Malay controls were determined using the microcytotoxicity assay. The strong association between DR2 (RR 3.28, P = 0.008) concurs with that reported among Chinese and Japanese populations. Moderate to strong associations with HLA-B 7 (RR 4.99, P = 0.02) and Cw 7 (RR 2.94, P = 0.003) were also found. We believe this is the first report of the association of HLA and SLE in the Malay population.

    Original languageEnglish
    Pages (from-to)393-395
    Number of pages3
    JournalLupus
    Volume3
    Issue number5
    Publication statusPublished - 1994

    Fingerprint

    HLA Antigens
    Systemic Lupus Erythematosus
    Antigens
    Population
    Phenotype

    Keywords

    • HLA
    • Malay
    • SLE

    ASJC Scopus subject areas

    • Immunology
    • Rheumatology

    Cite this

    Kong, N. C. T., Nasruruddin, B. A., Murad, S., Ong, K. J., & Sukumaran, K. D. (1994). HLA antigens in Malay patients with systemic lupus erythematosus. Lupus, 3(5), 393-395.

    HLA antigens in Malay patients with systemic lupus erythematosus. / Kong, N. C T; Nasruruddin, B. A.; Murad, S.; Ong, K. J.; Sukumaran, K. D.

    In: Lupus, Vol. 3, No. 5, 1994, p. 393-395.

    Research output: Contribution to journalArticle

    Kong, NCT, Nasruruddin, BA, Murad, S, Ong, KJ & Sukumaran, KD 1994, 'HLA antigens in Malay patients with systemic lupus erythematosus', Lupus, vol. 3, no. 5, pp. 393-395.
    Kong NCT, Nasruruddin BA, Murad S, Ong KJ, Sukumaran KD. HLA antigens in Malay patients with systemic lupus erythematosus. Lupus. 1994;3(5):393-395.
    Kong, N. C T ; Nasruruddin, B. A. ; Murad, S. ; Ong, K. J. ; Sukumaran, K. D. / HLA antigens in Malay patients with systemic lupus erythematosus. In: Lupus. 1994 ; Vol. 3, No. 5. pp. 393-395.
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